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Fusion gene ID: 13379 |
FusionGeneSummary for FGF2_FREM3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FGF2_FREM3 | Fusion gene ID: 13379 | Hgene | Tgene | Gene symbol | FGF2 | FREM3 | Gene ID | 2258 | 166752 |
| Gene name | fibroblast growth factor 13 | FRAS1 related extracellular matrix 3 | |
| Synonyms | FGF-13|FGF2|FHF-2|FHF2 | - | |
| Cytomap | Xq26.3-q27.1 | 4q31.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fibroblast growth factor 13fibroblast growth factor homologous factor 2 | FRAS1-related extracellular matrix protein 3 | |
| Modification date | 20180519 | 20180329 | |
| UniProtAcc | P09038 | P0C091 | |
| Ensembl transtripts involved in fusion gene | ENST00000264498, ENST00000608478, | ENST00000329798, ENST00000508899, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: FGF2 [Title/Abstract] AND FREM3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FGF2 | GO:0000165 | MAPK cascade | 12244047 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-A1L1-01A | FGF2 | chr4 | 123748507 | + | FREM3 | chr4 | 144548913 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000264498 | ENST00000329798 | FGF2 | chr4 | 123748507 | + | FREM3 | chr4 | 144548913 | - |
| 5CDS-intron | ENST00000264498 | ENST00000508899 | FGF2 | chr4 | 123748507 | + | FREM3 | chr4 | 144548913 | - |
| In-frame | ENST00000608478 | ENST00000329798 | FGF2 | chr4 | 123748507 | + | FREM3 | chr4 | 144548913 | - |
| 5CDS-intron | ENST00000608478 | ENST00000508899 | FGF2 | chr4 | 123748507 | + | FREM3 | chr4 | 144548913 | - |
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FusionProtFeatures for FGF2_FREM3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FGF2 | FREM3 |