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Fusion gene ID: 13314 |
FusionGeneSummary for FERMT1_RBBP7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FERMT1_RBBP7 | Fusion gene ID: 13314 | Hgene | Tgene | Gene symbol | FERMT1 | RBBP7 | Gene ID | 55612 | 5931 |
| Gene name | fermitin family member 1 | RB binding protein 7, chromatin remodeling factor | |
| Synonyms | C20orf42|DTGCU2|KIND1|UNC112A|URP1 | RbAp46 | |
| Cytomap | 20p12.3 | Xp22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fermitin family homolog 1UNC112 related protein 1kindlerinkindlin 1kindlin syndrome proteinunc-112-related protein 1 | histone-binding protein RBBP7G1/S transition control protein-binding protein RbAp46RBBP-7histone acetyltransferase type B subunit 2nucleosome-remodeling factor subunit RBAP46retinoblastoma-binding protein 7retinoblastoma-binding protein RbAp46retin | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9BQL6 | Q16576 | |
| Ensembl transtripts involved in fusion gene | ENST00000478194, ENST00000217289, ENST00000536936, | ENST00000380087, ENST00000380084, ENST00000404022, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 4 X 5 X 3=60 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/50*10)=0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FERMT1 [Title/Abstract] AND RBBP7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FERMT1 | GO:0007155 | cell adhesion | 17012746 |
| Hgene | FERMT1 | GO:0043616 | keratinocyte proliferation | 17012746 |
| Hgene | FERMT1 | GO:0051546 | keratinocyte migration | 17012746 |
| Hgene | FERMT1 | GO:0090162 | establishment of epithelial cell polarity | 17012746 |
| Tgene | RBBP7 | GO:0030308 | negative regulation of cell growth | 9765217 |
| Tgene | RBBP7 | GO:0070370 | cellular heat acclimation | 7503932 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW054656 | FERMT1 | chr20 | 6055568 | + | RBBP7 | chrX | 16862858 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000478194 | ENST00000380087 | FERMT1 | chr20 | 6055568 | + | RBBP7 | chrX | 16862858 | + |
| intron-3UTR | ENST00000478194 | ENST00000380084 | FERMT1 | chr20 | 6055568 | + | RBBP7 | chrX | 16862858 | + |
| intron-3UTR | ENST00000478194 | ENST00000404022 | FERMT1 | chr20 | 6055568 | + | RBBP7 | chrX | 16862858 | + |
| intron-3UTR | ENST00000217289 | ENST00000380087 | FERMT1 | chr20 | 6055568 | + | RBBP7 | chrX | 16862858 | + |
| intron-3UTR | ENST00000217289 | ENST00000380084 | FERMT1 | chr20 | 6055568 | + | RBBP7 | chrX | 16862858 | + |
| intron-3UTR | ENST00000217289 | ENST00000404022 | FERMT1 | chr20 | 6055568 | + | RBBP7 | chrX | 16862858 | + |
| intron-3UTR | ENST00000536936 | ENST00000380087 | FERMT1 | chr20 | 6055568 | + | RBBP7 | chrX | 16862858 | + |
| intron-3UTR | ENST00000536936 | ENST00000380084 | FERMT1 | chr20 | 6055568 | + | RBBP7 | chrX | 16862858 | + |
| intron-3UTR | ENST00000536936 | ENST00000404022 | FERMT1 | chr20 | 6055568 | + | RBBP7 | chrX | 16862858 | + |
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FusionProtFeatures for FERMT1_RBBP7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FERMT1 | RBBP7 |