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Fusion gene ID: 13270 |
FusionGeneSummary for FCHSD2_PLEKHB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FCHSD2_PLEKHB1 | Fusion gene ID: 13270 | Hgene | Tgene | Gene symbol | FCHSD2 | PLEKHB1 | Gene ID | 9873 | 58473 |
| Gene name | FCH and double SH3 domains 2 | pleckstrin homology domain containing B1 | |
| Synonyms | NWK|SH3MD3 | KPL1|PHR1|PHRET1 | |
| Cytomap | 11q13.4 | 11q13.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | F-BAR and double SH3 domains protein 2FCH and double SH3 domains protein 2SH3 multiple domains 3SH3 multiple domains protein 3caromnervous wreck homolog | pleckstrin homology domain-containing family B member 1PH domain containing, retinal 1PH domain-containing family B member 1PH domain-containing protein in retina 1evectin-1pleckstrin homology domain containing, family B (evectins) member 1pleckstri | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O94868 | Q9UF11 | |
| Ensembl transtripts involved in fusion gene | ENST00000311172, ENST00000409314, ENST00000409418, ENST00000458644, ENST00000409853, ENST00000409263, | ENST00000354190, ENST00000398492, ENST00000227214, ENST00000398494, ENST00000543085, ENST00000544532, ENST00000535129, | |
| Fusion gene scores | * DoF score | 29 X 12 X 13=4524 | 6 X 6 X 4=144 |
| # samples | 33 | 7 | |
| ** MAII score | log2(33/4524*10)=-3.777060999744 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FCHSD2 [Title/Abstract] AND PLEKHB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A8-A07E-01A | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000311172 | ENST00000354190 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| intron-3CDS | ENST00000311172 | ENST00000398492 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| intron-3CDS | ENST00000311172 | ENST00000227214 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| intron-3CDS | ENST00000311172 | ENST00000398494 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| intron-3CDS | ENST00000311172 | ENST00000543085 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| intron-intron | ENST00000311172 | ENST00000544532 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| intron-intron | ENST00000311172 | ENST00000535129 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| Frame-shift | ENST00000409314 | ENST00000354190 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| Frame-shift | ENST00000409314 | ENST00000398492 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| Frame-shift | ENST00000409314 | ENST00000227214 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| Frame-shift | ENST00000409314 | ENST00000398494 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| Frame-shift | ENST00000409314 | ENST00000543085 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5CDS-intron | ENST00000409314 | ENST00000544532 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5CDS-intron | ENST00000409314 | ENST00000535129 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| Frame-shift | ENST00000409418 | ENST00000354190 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| Frame-shift | ENST00000409418 | ENST00000398492 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| Frame-shift | ENST00000409418 | ENST00000227214 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| Frame-shift | ENST00000409418 | ENST00000398494 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| Frame-shift | ENST00000409418 | ENST00000543085 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5CDS-intron | ENST00000409418 | ENST00000544532 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5CDS-intron | ENST00000409418 | ENST00000535129 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5UTR-3CDS | ENST00000458644 | ENST00000354190 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5UTR-3CDS | ENST00000458644 | ENST00000398492 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5UTR-3CDS | ENST00000458644 | ENST00000227214 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5UTR-3CDS | ENST00000458644 | ENST00000398494 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5UTR-3CDS | ENST00000458644 | ENST00000543085 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5UTR-intron | ENST00000458644 | ENST00000544532 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5UTR-intron | ENST00000458644 | ENST00000535129 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5UTR-3CDS | ENST00000409853 | ENST00000354190 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5UTR-3CDS | ENST00000409853 | ENST00000398492 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5UTR-3CDS | ENST00000409853 | ENST00000227214 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5UTR-3CDS | ENST00000409853 | ENST00000398494 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5UTR-3CDS | ENST00000409853 | ENST00000543085 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5UTR-intron | ENST00000409853 | ENST00000544532 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| 5UTR-intron | ENST00000409853 | ENST00000535129 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| intron-3CDS | ENST00000409263 | ENST00000354190 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| intron-3CDS | ENST00000409263 | ENST00000398492 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| intron-3CDS | ENST00000409263 | ENST00000227214 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| intron-3CDS | ENST00000409263 | ENST00000398494 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| intron-3CDS | ENST00000409263 | ENST00000543085 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| intron-intron | ENST00000409263 | ENST00000544532 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
| intron-intron | ENST00000409263 | ENST00000535129 | FCHSD2 | chr11 | 72851076 | - | PLEKHB1 | chr11 | 73371798 | + |
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FusionProtFeatures for FCHSD2_PLEKHB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FCHSD2 | PLEKHB1 |