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Fusion gene ID: 13223 |
FusionGeneSummary for FBXW7_MGST2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FBXW7_MGST2 | Fusion gene ID: 13223 | Hgene | Tgene | Gene symbol | FBXW7 | MGST2 | Gene ID | 55294 | 4258 |
| Gene name | F-box and WD repeat domain containing 7 | microsomal glutathione S-transferase 2 | |
| Synonyms | AGO|CDC4|FBW6|FBW7|FBX30|FBXO30|FBXW6|SEL-10|SEL10|hAgo|hCdc4 | GST2|MGST-II | |
| Cytomap | 4q31.3 | 4q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | F-box/WD repeat-containing protein 7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligaseF-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)F-box protein FBW7F-box protein FBX30F-box protein SEL-10archipelagohomolog of | microsomal glutathione S-transferase 2microsomal GST-2microsomal GST-II | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q969H0 | Q99735 | |
| Ensembl transtripts involved in fusion gene | ENST00000281708, ENST00000603548, ENST00000604872, ENST00000296555, ENST00000263981, ENST00000393956, ENST00000603841, ENST00000604095, | ENST00000515137, ENST00000265498, ENST00000506797, | |
| Fusion gene scores | * DoF score | 9 X 5 X 7=315 | 7 X 4 X 6=168 |
| # samples | 10 | 8 | |
| ** MAII score | log2(10/315*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FBXW7 [Title/Abstract] AND MGST2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FBXW7 | GO:0016567 | protein ubiquitination | 12354302|15103331 |
| Hgene | FBXW7 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 15103331|17434132 |
| Hgene | FBXW7 | GO:0031398 | positive regulation of protein ubiquitination | 12628165 |
| Hgene | FBXW7 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity | 20208556 |
| Hgene | FBXW7 | GO:0050821 | protein stabilization | 20208556 |
| Hgene | FBXW7 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity | 12628165 |
| Hgene | FBXW7 | GO:1901800 | positive regulation of proteasomal protein catabolic process | 23858059 |
| Hgene | FBXW7 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | 23858059 |
| Hgene | FBXW7 | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 20208556 |
| Tgene | MGST2 | GO:0006629 | lipid metabolic process | 9278457 |
| Tgene | MGST2 | GO:0006750 | glutathione biosynthetic process | 8703034 |
| Tgene | MGST2 | GO:0019370 | leukotriene biosynthetic process | 8703034|9092565|23409838 |
| Tgene | MGST2 | GO:0046466 | membrane lipid catabolic process | 23409838 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A1-A0SP-01A | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000281708 | ENST00000515137 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| 5CDS-intron | ENST00000281708 | ENST00000265498 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| 5CDS-intron | ENST00000281708 | ENST00000506797 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| 5CDS-3UTR | ENST00000603548 | ENST00000515137 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| 5CDS-intron | ENST00000603548 | ENST00000265498 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| 5CDS-intron | ENST00000603548 | ENST00000506797 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| intron-3UTR | ENST00000604872 | ENST00000515137 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| intron-intron | ENST00000604872 | ENST00000265498 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| intron-intron | ENST00000604872 | ENST00000506797 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| 5CDS-3UTR | ENST00000296555 | ENST00000515137 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| 5CDS-intron | ENST00000296555 | ENST00000265498 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| 5CDS-intron | ENST00000296555 | ENST00000506797 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| 5CDS-3UTR | ENST00000263981 | ENST00000515137 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| 5CDS-intron | ENST00000263981 | ENST00000265498 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| 5CDS-intron | ENST00000263981 | ENST00000506797 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| 5CDS-3UTR | ENST00000393956 | ENST00000515137 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| 5CDS-intron | ENST00000393956 | ENST00000265498 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| 5CDS-intron | ENST00000393956 | ENST00000506797 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| 5CDS-3UTR | ENST00000603841 | ENST00000515137 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| 5CDS-intron | ENST00000603841 | ENST00000265498 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| 5CDS-intron | ENST00000603841 | ENST00000506797 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| intron-3UTR | ENST00000604095 | ENST00000515137 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| intron-intron | ENST00000604095 | ENST00000265498 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
| intron-intron | ENST00000604095 | ENST00000506797 | FBXW7 | chr4 | 153268082 | - | MGST2 | chr4 | 140661366 | + |
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FusionProtFeatures for FBXW7_MGST2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FBXW7 | MGST2 |