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Fusion gene ID: 13190 |
FusionGeneSummary for FBXO46_ARG2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FBXO46_ARG2 | Fusion gene ID: 13190 | Hgene | Tgene | Gene symbol | FBXO46 | ARG2 | Gene ID | 23403 | 384 |
| Gene name | F-box protein 46 | arginase 2 | |
| Synonyms | 20D7-FC4|FBXO34L|Fbx46 | - | |
| Cytomap | 19q13.32 | 14q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | F-box only protein 46 | arginase-2, mitochondrialL-arginine amidinohydrolaseL-arginine ureahydrolasearginase IIarginase, type IIkidney arginasekidney-type arginasenon-hepatic arginasenonhepatic arginasetype II arginase | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q6PJ61 | P78540 | |
| Ensembl transtripts involved in fusion gene | ENST00000317683, | ENST00000261783, ENST00000556491, | |
| Fusion gene scores | * DoF score | 4 X 1 X 4=16 | 5 X 4 X 5=100 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FBXO46 [Title/Abstract] AND ARG2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ARG2 | GO:2000774 | positive regulation of cellular senescence | 22928666 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-A5-A2K4-01A | FBXO46 | chr19 | 46234107 | - | ARG2 | chr14 | 68108903 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000317683 | ENST00000261783 | FBXO46 | chr19 | 46234107 | - | ARG2 | chr14 | 68108903 | + |
| 5UTR-3UTR | ENST00000317683 | ENST00000556491 | FBXO46 | chr19 | 46234107 | - | ARG2 | chr14 | 68108903 | + |
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FusionProtFeatures for FBXO46_ARG2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FBXO46 | ARG2 |