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Fusion gene ID: 13165 |
FusionGeneSummary for FBXO34_ATG7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FBXO34_ATG7 | Fusion gene ID: 13165 | Hgene | Tgene | Gene symbol | FBXO34 | ATG7 | Gene ID | 55030 | 10533 |
| Gene name | F-box protein 34 | autophagy related 7 | |
| Synonyms | CGI-301|Fbx34 | APG7-LIKE|APG7L|GSA7 | |
| Cytomap | 14q22.3 | 3p25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | F-box only protein 34protein CGI-301 | ubiquitin-like modifier-activating enzyme ATG7APG7 autophagy 7-likeATG12-activating enzyme E1 ATG7hAGP7ubiquitin-activating enzyme E1-like protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NWN3 | O95352 | |
| Ensembl transtripts involved in fusion gene | ENST00000313833, ENST00000555087, ENST00000440021, | ENST00000446450, ENST00000354956, ENST00000354449, ENST00000469654, | |
| Fusion gene scores | * DoF score | 8 X 5 X 5=200 | 11 X 11 X 7=847 |
| # samples | 10 | 15 | |
| ** MAII score | log2(10/200*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/847*10)=-2.49739946883632 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FBXO34 [Title/Abstract] AND ATG7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ATG7 | GO:0006497 | protein lipidation | 12890687 |
| Tgene | ATG7 | GO:0009267 | cellular response to starvation | 20543840 |
| Tgene | ATG7 | GO:0031401 | positive regulation of protein modification process | 12890687 |
| Tgene | ATG7 | GO:0071455 | cellular response to hyperoxia | 20543840 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-V1-A8WL-01A | FBXO34 | chr14 | 55738255 | + | ATG7 | chr3 | 11596285 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000313833 | ENST00000446450 | FBXO34 | chr14 | 55738255 | + | ATG7 | chr3 | 11596285 | + |
| 5UTR-3CDS | ENST00000313833 | ENST00000354956 | FBXO34 | chr14 | 55738255 | + | ATG7 | chr3 | 11596285 | + |
| 5UTR-3CDS | ENST00000313833 | ENST00000354449 | FBXO34 | chr14 | 55738255 | + | ATG7 | chr3 | 11596285 | + |
| 5UTR-intron | ENST00000313833 | ENST00000469654 | FBXO34 | chr14 | 55738255 | + | ATG7 | chr3 | 11596285 | + |
| intron-3CDS | ENST00000555087 | ENST00000446450 | FBXO34 | chr14 | 55738255 | + | ATG7 | chr3 | 11596285 | + |
| intron-3CDS | ENST00000555087 | ENST00000354956 | FBXO34 | chr14 | 55738255 | + | ATG7 | chr3 | 11596285 | + |
| intron-3CDS | ENST00000555087 | ENST00000354449 | FBXO34 | chr14 | 55738255 | + | ATG7 | chr3 | 11596285 | + |
| intron-intron | ENST00000555087 | ENST00000469654 | FBXO34 | chr14 | 55738255 | + | ATG7 | chr3 | 11596285 | + |
| intron-3CDS | ENST00000440021 | ENST00000446450 | FBXO34 | chr14 | 55738255 | + | ATG7 | chr3 | 11596285 | + |
| intron-3CDS | ENST00000440021 | ENST00000354956 | FBXO34 | chr14 | 55738255 | + | ATG7 | chr3 | 11596285 | + |
| intron-3CDS | ENST00000440021 | ENST00000354449 | FBXO34 | chr14 | 55738255 | + | ATG7 | chr3 | 11596285 | + |
| intron-intron | ENST00000440021 | ENST00000469654 | FBXO34 | chr14 | 55738255 | + | ATG7 | chr3 | 11596285 | + |
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FusionProtFeatures for FBXO34_ATG7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FBXO34 | ATG7 |