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Fusion gene ID: 13137 |
FusionGeneSummary for FBXL7_PTPN3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FBXL7_PTPN3 | Fusion gene ID: 13137 | Hgene | Tgene | Gene symbol | FBXL7 | PTPN3 | Gene ID | 23194 | 5774 |
| Gene name | F-box and leucine rich repeat protein 7 | protein tyrosine phosphatase, non-receptor type 3 | |
| Synonyms | FBL6|FBL7 | PTP-H1|PTPH1 | |
| Cytomap | 5p15.1 | 9q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | F-box/LRR-repeat protein 7F-box protein Fbl7 | tyrosine-protein phosphatase non-receptor type 3cytoskeletal-associated protein tyrosine phosphataseprotein-tyrosine phosphatase H1 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9UJT9 | P26045 | |
| Ensembl transtripts involved in fusion gene | ENST00000504595, ENST00000510662, ENST00000329673, | ENST00000412145, ENST00000446349, ENST00000374541, ENST00000262539, ENST00000394827, ENST00000497739, | |
| Fusion gene scores | * DoF score | 10 X 5 X 5=250 | 4 X 4 X 3=48 |
| # samples | 11 | 4 | |
| ** MAII score | log2(11/250*10)=-1.18442457113743 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FBXL7 [Title/Abstract] AND PTPN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PTPN3 | GO:0006470 | protein dephosphorylation | 10364224 |
| Tgene | PTPN3 | GO:0045930 | negative regulation of mitotic cell cycle | 10364224 |
| Tgene | PTPN3 | GO:0098902 | regulation of membrane depolarization during action potential | 16930557 |
| Tgene | PTPN3 | GO:2000649 | regulation of sodium ion transmembrane transporter activity | 16930557 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A1KZ-01A | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000504595 | ENST00000412145 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| Frame-shift | ENST00000504595 | ENST00000446349 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| Frame-shift | ENST00000504595 | ENST00000374541 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| Frame-shift | ENST00000504595 | ENST00000262539 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| 5CDS-intron | ENST00000504595 | ENST00000394827 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| 5CDS-intron | ENST00000504595 | ENST00000497739 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| 5UTR-3CDS | ENST00000510662 | ENST00000412145 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| 5UTR-3CDS | ENST00000510662 | ENST00000446349 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| 5UTR-3CDS | ENST00000510662 | ENST00000374541 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| 5UTR-3CDS | ENST00000510662 | ENST00000262539 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| 5UTR-intron | ENST00000510662 | ENST00000394827 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| 5UTR-intron | ENST00000510662 | ENST00000497739 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| Frame-shift | ENST00000329673 | ENST00000412145 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| Frame-shift | ENST00000329673 | ENST00000446349 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| Frame-shift | ENST00000329673 | ENST00000374541 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| Frame-shift | ENST00000329673 | ENST00000262539 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| 5CDS-intron | ENST00000329673 | ENST00000394827 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
| 5CDS-intron | ENST00000329673 | ENST00000497739 | FBXL7 | chr5 | 15616181 | + | PTPN3 | chr9 | 112190964 | - |
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FusionProtFeatures for FBXL7_PTPN3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FBXL7 | PTPN3 |