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Fusion gene ID: 13123 |
FusionGeneSummary for FBXL4_APBA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FBXL4_APBA2 | Fusion gene ID: 13123 | Hgene | Tgene | Gene symbol | FBXL4 | APBA2 | Gene ID | 26235 | 321 |
| Gene name | F-box and leucine rich repeat protein 4 | amyloid beta precursor protein binding family A member 2 | |
| Synonyms | FBL4|FBL5|MTDPS13 | D15S1518E|HsT16821|LIN-10|MGC:14091|MINT2|X11-BETA|X11L | |
| Cytomap | 6q16.1-q16.2 | 15q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | F-box/LRR-repeat protein 4 | amyloid-beta A4 precursor protein-binding family A member 2X11-like proteinadapter protein X11betaamyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like)mint-2neuron-specific X11L proteinneuronal munc18-1-interacting protein 2pho | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UKA2 | Q99767 | |
| Ensembl transtripts involved in fusion gene | ENST00000369244, ENST00000229971, | ENST00000561069, ENST00000558402, ENST00000558330, ENST00000411764, ENST00000558259, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/50*10)=0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: FBXL4 [Title/Abstract] AND APBA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF885322 | FBXL4 | chr6 | 99347218 | + | APBA2 | chr15 | 29368266 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000369244 | ENST00000561069 | FBXL4 | chr6 | 99347218 | + | APBA2 | chr15 | 29368266 | + |
| intron-3CDS | ENST00000369244 | ENST00000558402 | FBXL4 | chr6 | 99347218 | + | APBA2 | chr15 | 29368266 | + |
| intron-3CDS | ENST00000369244 | ENST00000558330 | FBXL4 | chr6 | 99347218 | + | APBA2 | chr15 | 29368266 | + |
| intron-3CDS | ENST00000369244 | ENST00000411764 | FBXL4 | chr6 | 99347218 | + | APBA2 | chr15 | 29368266 | + |
| intron-3CDS | ENST00000369244 | ENST00000558259 | FBXL4 | chr6 | 99347218 | + | APBA2 | chr15 | 29368266 | + |
| intron-3CDS | ENST00000229971 | ENST00000561069 | FBXL4 | chr6 | 99347218 | + | APBA2 | chr15 | 29368266 | + |
| intron-3CDS | ENST00000229971 | ENST00000558402 | FBXL4 | chr6 | 99347218 | + | APBA2 | chr15 | 29368266 | + |
| intron-3CDS | ENST00000229971 | ENST00000558330 | FBXL4 | chr6 | 99347218 | + | APBA2 | chr15 | 29368266 | + |
| intron-3CDS | ENST00000229971 | ENST00000411764 | FBXL4 | chr6 | 99347218 | + | APBA2 | chr15 | 29368266 | + |
| intron-3CDS | ENST00000229971 | ENST00000558259 | FBXL4 | chr6 | 99347218 | + | APBA2 | chr15 | 29368266 | + |
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FusionProtFeatures for FBXL4_APBA2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FBXL4 | APBA2 |