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Fusion gene ID: 13121 |
FusionGeneSummary for FBXL3_MYCBP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FBXL3_MYCBP2 | Fusion gene ID: 13121 | Hgene | Tgene | Gene symbol | FBXL3 | MYCBP2 | Gene ID | 26224 | 23077 |
| Gene name | F-box and leucine rich repeat protein 3 | MYC binding protein 2, E3 ubiquitin protein ligase | |
| Synonyms | FBL3|FBL3A|FBXL3A | Myc-bp2|PAM|Phr | |
| Cytomap | 13q22.3 | 13q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | F-box/LRR-repeat protein 3F-box and leucine-rich repeat protein 3AF-box protein Fbl3aF-box/LRR-repeat protein 3A | E3 ubiquitin-protein ligase MYCBP2HighwireRING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with Myc | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UKT7 | O75592 | |
| Ensembl transtripts involved in fusion gene | ENST00000355619, ENST00000477982, | ENST00000544440, ENST00000407578, ENST00000357337, ENST00000360084, ENST00000482517, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 2 X 4 X 2=16 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/16*10)=0.906890595608518 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FBXL3 [Title/Abstract] AND MYCBP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FBXL3 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 17463251 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-V1-A8WV-01A | FBXL3 | chr13 | 77589544 | - | MYCBP2 | chr13 | 77625297 | - |
| TCGA | LD | STAD | TCGA-RD-A8N9-01A | FBXL3 | chr13 | 77600962 | - | MYCBP2 | chr13 | 77752089 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000355619 | ENST00000544440 | FBXL3 | chr13 | 77589544 | - | MYCBP2 | chr13 | 77625297 | - |
| Frame-shift | ENST00000355619 | ENST00000407578 | FBXL3 | chr13 | 77589544 | - | MYCBP2 | chr13 | 77625297 | - |
| Frame-shift | ENST00000355619 | ENST00000357337 | FBXL3 | chr13 | 77589544 | - | MYCBP2 | chr13 | 77625297 | - |
| 5CDS-intron | ENST00000355619 | ENST00000360084 | FBXL3 | chr13 | 77589544 | - | MYCBP2 | chr13 | 77625297 | - |
| 5CDS-intron | ENST00000355619 | ENST00000482517 | FBXL3 | chr13 | 77589544 | - | MYCBP2 | chr13 | 77625297 | - |
| 5UTR-3CDS | ENST00000477982 | ENST00000544440 | FBXL3 | chr13 | 77589544 | - | MYCBP2 | chr13 | 77625297 | - |
| 5UTR-3CDS | ENST00000477982 | ENST00000407578 | FBXL3 | chr13 | 77589544 | - | MYCBP2 | chr13 | 77625297 | - |
| 5UTR-3CDS | ENST00000477982 | ENST00000357337 | FBXL3 | chr13 | 77589544 | - | MYCBP2 | chr13 | 77625297 | - |
| 5UTR-intron | ENST00000477982 | ENST00000360084 | FBXL3 | chr13 | 77589544 | - | MYCBP2 | chr13 | 77625297 | - |
| 5UTR-intron | ENST00000477982 | ENST00000482517 | FBXL3 | chr13 | 77589544 | - | MYCBP2 | chr13 | 77625297 | - |
| 5UTR-3CDS | ENST00000355619 | ENST00000544440 | FBXL3 | chr13 | 77600962 | - | MYCBP2 | chr13 | 77752089 | - |
| 5UTR-3CDS | ENST00000355619 | ENST00000407578 | FBXL3 | chr13 | 77600962 | - | MYCBP2 | chr13 | 77752089 | - |
| 5UTR-3CDS | ENST00000355619 | ENST00000357337 | FBXL3 | chr13 | 77600962 | - | MYCBP2 | chr13 | 77752089 | - |
| 5UTR-5UTR | ENST00000355619 | ENST00000360084 | FBXL3 | chr13 | 77600962 | - | MYCBP2 | chr13 | 77752089 | - |
| 5UTR-intron | ENST00000355619 | ENST00000482517 | FBXL3 | chr13 | 77600962 | - | MYCBP2 | chr13 | 77752089 | - |
| intron-3CDS | ENST00000477982 | ENST00000544440 | FBXL3 | chr13 | 77600962 | - | MYCBP2 | chr13 | 77752089 | - |
| intron-3CDS | ENST00000477982 | ENST00000407578 | FBXL3 | chr13 | 77600962 | - | MYCBP2 | chr13 | 77752089 | - |
| intron-3CDS | ENST00000477982 | ENST00000357337 | FBXL3 | chr13 | 77600962 | - | MYCBP2 | chr13 | 77752089 | - |
| intron-5UTR | ENST00000477982 | ENST00000360084 | FBXL3 | chr13 | 77600962 | - | MYCBP2 | chr13 | 77752089 | - |
| intron-intron | ENST00000477982 | ENST00000482517 | FBXL3 | chr13 | 77600962 | - | MYCBP2 | chr13 | 77752089 | - |
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FusionProtFeatures for FBXL3_MYCBP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FBXL3 | MYCBP2 |