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Fusion gene ID: 1312 |
FusionGeneSummary for AKAP13_CASC4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AKAP13_CASC4 | Fusion gene ID: 1312 | Hgene | Tgene | Gene symbol | AKAP13 | CASC4 | Gene ID | 11214 | 113201 |
| Gene name | A-kinase anchoring protein 13 | cancer susceptibility 4 | |
| Synonyms | AKAP-13|AKAP-Lbc|ARHGEF13|BRX|HA-3|Ht31|LBC|PRKA13|PROTO-LB|PROTO-LBC|c-lbc|p47 | H63 | |
| Cytomap | 15q25.3 | 15q15.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | A-kinase anchor protein 13A kinase (PRKA) anchor protein 13LBC oncogenebreast cancer nuclear receptor-binding auxiliary proteinguanine nucleotide exchange factor Lbchuman thyroid-anchoring protein 31lymphoid blast crisis oncogenenon-oncogenic Rho G | protein CASC4cancer susceptibility candidate 4cancer susceptibility candidate gene 4 proteingene associated with HER-2/neu overexpression | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q12802 | Q6P4E1 | |
| Ensembl transtripts involved in fusion gene | ENST00000560302, ENST00000394518, ENST00000361243, ENST00000560579, ENST00000394510, | ENST00000299957, ENST00000360824, ENST00000345795, ENST00000429162, | |
| Fusion gene scores | * DoF score | 21 X 16 X 12=4032 | 5 X 7 X 5=175 |
| # samples | 22 | 9 | |
| ** MAII score | log2(22/4032*10)=-4.19592020997526 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/175*10)=-0.959358015502654 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AKAP13 [Title/Abstract] AND CASC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AKAP13 | GO:0007186 | G-protein coupled receptor signaling pathway | 11546812 |
| Hgene | AKAP13 | GO:0035025 | positive regulation of Rho protein signal transduction | 11546812 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | MESO | TCGA-LK-A4NY-01A | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000560302 | ENST00000299957 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| intron-intron | ENST00000560302 | ENST00000360824 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| intron-intron | ENST00000560302 | ENST00000345795 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| intron-intron | ENST00000560302 | ENST00000429162 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| Frame-shift | ENST00000394518 | ENST00000299957 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| 5CDS-intron | ENST00000394518 | ENST00000360824 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| 5CDS-intron | ENST00000394518 | ENST00000345795 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| 5CDS-intron | ENST00000394518 | ENST00000429162 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| Frame-shift | ENST00000361243 | ENST00000299957 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| 5CDS-intron | ENST00000361243 | ENST00000360824 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| 5CDS-intron | ENST00000361243 | ENST00000345795 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| 5CDS-intron | ENST00000361243 | ENST00000429162 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| intron-3CDS | ENST00000560579 | ENST00000299957 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| intron-intron | ENST00000560579 | ENST00000360824 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| intron-intron | ENST00000560579 | ENST00000345795 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| intron-intron | ENST00000560579 | ENST00000429162 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| intron-3CDS | ENST00000394510 | ENST00000299957 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| intron-intron | ENST00000394510 | ENST00000360824 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| intron-intron | ENST00000394510 | ENST00000345795 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
| intron-intron | ENST00000394510 | ENST00000429162 | AKAP13 | chr15 | 86129054 | + | CASC4 | chr15 | 44624186 | + |
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FusionProtFeatures for AKAP13_CASC4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AKAP13 | CASC4 |