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Fusion gene ID: 13080

FusionGeneSummary for FBXL20_CASS4

Fusion gene summary

Fusion gene information	Fusion gene name: FBXL20_CASS4
	Fusion gene ID: 13080
		Hgene	Tgene
	Gene symbol	FBXL20	CASS4
	Gene ID	84961	57091
	Gene name	F-box and leucine rich repeat protein 20	Cas scaffold protein family member 4
	Synonyms	Fbl2\|Fbl20	C20orf32\|CAS4\|HEFL\|HEPL
	Cytomap	17q12	20q13.31
	Type of gene	protein-coding	protein-coding
	Description	F-box/LRR-repeat protein 20F-box protein FBL2	cas scaffolding protein family member 4HEF-like proteinHEF1-EFS-p130Cas-like protein
	Modification date	20180523	20180523
	UniProtAcc	Q96IG2	Q9NQ75
	Ensembl transtripts involved in fusion gene	ENST00000583610, ENST00000394294, ENST00000264658, ENST00000577399,	ENST00000360314, ENST00000371336, ENST00000434344,
Fusion gene scores	* DoF score	40 X 12 X 14=6720	5 X 2 X 3=30
	# samples	38	5
	** MAII score	log2(38/6720*10)=-4.14438990933518 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/30*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: FBXL20 [Title/Abstract] AND CASS4 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-AN-A0FV-01A	FBXL20	chr17	37557614	-	CASS4	chr20	55020956	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000583610	ENST00000360314	FBXL20	chr17	37557614	-	CASS4	chr20	55020956	+
In-frame	ENST00000583610	ENST00000371336	FBXL20	chr17	37557614	-	CASS4	chr20	55020956	+
In-frame	ENST00000583610	ENST00000434344	FBXL20	chr17	37557614	-	CASS4	chr20	55020956	+
In-frame	ENST00000394294	ENST00000360314	FBXL20	chr17	37557614	-	CASS4	chr20	55020956	+
In-frame	ENST00000394294	ENST00000371336	FBXL20	chr17	37557614	-	CASS4	chr20	55020956	+
In-frame	ENST00000394294	ENST00000434344	FBXL20	chr17	37557614	-	CASS4	chr20	55020956	+
In-frame	ENST00000264658	ENST00000360314	FBXL20	chr17	37557614	-	CASS4	chr20	55020956	+
In-frame	ENST00000264658	ENST00000371336	FBXL20	chr17	37557614	-	CASS4	chr20	55020956	+
In-frame	ENST00000264658	ENST00000434344	FBXL20	chr17	37557614	-	CASS4	chr20	55020956	+
intron-3CDS	ENST00000577399	ENST00000360314	FBXL20	chr17	37557614	-	CASS4	chr20	55020956	+
intron-3CDS	ENST00000577399	ENST00000371336	FBXL20	chr17	37557614	-	CASS4	chr20	55020956	+
intron-3CDS	ENST00000577399	ENST00000434344	FBXL20	chr17	37557614	-	CASS4	chr20	55020956	+

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FusionProtFeatures for FBXL20_CASS4

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FBXL20 Q96IG2	CASS4 Q9NQ75

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Fusion gene ID: 13080

FusionGeneSummary for FBXL20_CASS4

FusionProtFeatures for FBXL20_CASS4