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Fusion gene ID: 13036 |
FusionGeneSummary for FBN1_TEX9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FBN1_TEX9 | Fusion gene ID: 13036 | Hgene | Tgene | Gene symbol | FBN1 | TEX9 | Gene ID | 2200 | 374618 |
| Gene name | fibrillin 1 | testis expressed 9 | |
| Synonyms | ACMICD|ECTOL1|FBN|GPHYSD2|MASS|MFLS|MFS1|OCTD|SGS|SSKS|WMS|WMS2 | - | |
| Cytomap | 15q21.1 | 15q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fibrillin-1asprosinfibrillin 15fibrillin-1 preproprotein | testis-expressed protein 9testis-expressed sequence 9 protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P35555 | Q8N6V9 | |
| Ensembl transtripts involved in fusion gene | ENST00000316623, ENST00000561429, ENST00000560355, | ENST00000352903, ENST00000537232, ENST00000561221, ENST00000558083, ENST00000559142, ENST00000560582, | |
| Fusion gene scores | * DoF score | 8 X 8 X 4=256 | 4 X 5 X 3=60 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/256*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FBN1 [Title/Abstract] AND TEX9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FBN1 | GO:0033627 | cell adhesion mediated by integrin | 12807887|17158881 |
| Hgene | FBN1 | GO:0045671 | negative regulation of osteoclast differentiation | 24039232 |
| Hgene | FBN1 | GO:2001205 | negative regulation of osteoclast development | 24039232 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | MESO | TCGA-TS-A8AF-01A | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000316623 | ENST00000352903 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| In-frame | ENST00000316623 | ENST00000537232 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| In-frame | ENST00000316623 | ENST00000561221 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| In-frame | ENST00000316623 | ENST00000558083 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| 5CDS-intron | ENST00000316623 | ENST00000559142 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| 5CDS-intron | ENST00000316623 | ENST00000560582 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| intron-3CDS | ENST00000561429 | ENST00000352903 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| intron-3CDS | ENST00000561429 | ENST00000537232 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| intron-3CDS | ENST00000561429 | ENST00000561221 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| intron-3CDS | ENST00000561429 | ENST00000558083 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| intron-intron | ENST00000561429 | ENST00000559142 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| intron-intron | ENST00000561429 | ENST00000560582 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| intron-3CDS | ENST00000560355 | ENST00000352903 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| intron-3CDS | ENST00000560355 | ENST00000537232 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| intron-3CDS | ENST00000560355 | ENST00000561221 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| intron-3CDS | ENST00000560355 | ENST00000558083 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| intron-intron | ENST00000560355 | ENST00000559142 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
| intron-intron | ENST00000560355 | ENST00000560582 | FBN1 | chr15 | 48905207 | - | TEX9 | chr15 | 56686363 | + |
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FusionProtFeatures for FBN1_TEX9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FBN1 | TEX9 |