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Fusion gene ID: 1295 |
FusionGeneSummary for AK8_GPR107 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AK8_GPR107 | Fusion gene ID: 1295 | Hgene | Tgene | Gene symbol | AK8 | GPR107 | Gene ID | 158067 | 57720 |
| Gene name | adenylate kinase 8 | G protein-coupled receptor 107 | |
| Synonyms | AK 8|C9orf98|DDX31 | GCDRP|LUSTR1|bA138E2.2 | |
| Cytomap | 9q34.13 | 9q34.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | adenylate kinase 8ATP-AMP transphosphorylase 8putative adenylate kinase-like protein C9orf98 | protein GPR107lung seven transmembrane receptor 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q96MA6 | Q5VW38 | |
| Ensembl transtripts involved in fusion gene | ENST00000477396, ENST00000298545, | ENST00000347136, ENST00000372406, ENST00000372410, ENST00000415344, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 6 X 6 X 2=72 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AK8 [Title/Abstract] AND GPR107 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AK8 | GO:0006165 | nucleoside diphosphate phosphorylation | 23416111 |
| Hgene | AK8 | GO:0009142 | nucleoside triphosphate biosynthetic process | 23416111 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF957859 | AK8 | chr9 | 135734546 | - | GPR107 | chr9 | 132898239 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000477396 | ENST00000347136 | AK8 | chr9 | 135734546 | - | GPR107 | chr9 | 132898239 | + |
| intron-3UTR | ENST00000477396 | ENST00000372406 | AK8 | chr9 | 135734546 | - | GPR107 | chr9 | 132898239 | + |
| intron-3UTR | ENST00000477396 | ENST00000372410 | AK8 | chr9 | 135734546 | - | GPR107 | chr9 | 132898239 | + |
| intron-intron | ENST00000477396 | ENST00000415344 | AK8 | chr9 | 135734546 | - | GPR107 | chr9 | 132898239 | + |
| intron-3UTR | ENST00000298545 | ENST00000347136 | AK8 | chr9 | 135734546 | - | GPR107 | chr9 | 132898239 | + |
| intron-3UTR | ENST00000298545 | ENST00000372406 | AK8 | chr9 | 135734546 | - | GPR107 | chr9 | 132898239 | + |
| intron-3UTR | ENST00000298545 | ENST00000372410 | AK8 | chr9 | 135734546 | - | GPR107 | chr9 | 132898239 | + |
| intron-intron | ENST00000298545 | ENST00000415344 | AK8 | chr9 | 135734546 | - | GPR107 | chr9 | 132898239 | + |
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FusionProtFeatures for AK8_GPR107 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AK8 | GPR107 |