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Fusion gene ID: 12916 |
FusionGeneSummary for FANCC_ROR2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FANCC_ROR2 | Fusion gene ID: 12916 | Hgene | Tgene | Gene symbol | FANCC | ROR2 | Gene ID | 2176 | 6095 |
| Gene name | FA complementation group C | RAR related orphan receptor A | |
| Synonyms | FA3|FAC|FACC | NR1F1|ROR1|ROR2|ROR3|RZR-ALPHA|RZRA | |
| Cytomap | 9q22.32 | 15q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | Fanconi anemia group C proteinFanconi anemia complementation group C | nuclear receptor ROR-alphaROR-alphanuclear receptor RZR-alphanuclear receptor subfamily 1 group F member 1retinoic acid receptor-related orphan receptor alpharetinoid-related orphan receptor alphathyroid hormone nuclear receptor alpha variant 4tran | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q00597 | Q01974 | |
| Ensembl transtripts involved in fusion gene | ENST00000289081, ENST00000375305, ENST00000464653, | ENST00000375715, ENST00000375708, ENST00000550066, | |
| Fusion gene scores | * DoF score | 7 X 5 X 6=210 | 2 X 2 X 2=8 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: FANCC [Title/Abstract] AND ROR2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ROR2 | GO:0006355 | regulation of transcription, DNA-templated | 9328355 |
| Tgene | ROR2 | GO:0030522 | intracellular receptor signaling pathway | 19965867 |
| Tgene | ROR2 | GO:0036315 | cellular response to sterol | 19965867 |
| Tgene | ROR2 | GO:0045893 | positive regulation of transcription, DNA-templated | 7926749 |
| Tgene | ROR2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17545671|19955433 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-XQ-A8TA-01A | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000289081 | ENST00000375715 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| 5CDS-5UTR | ENST00000289081 | ENST00000375708 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| 5CDS-5UTR | ENST00000289081 | ENST00000550066 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| 5CDS-5UTR | ENST00000375305 | ENST00000375715 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| 5CDS-5UTR | ENST00000375305 | ENST00000375708 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| 5CDS-5UTR | ENST00000375305 | ENST00000550066 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| intron-5UTR | ENST00000464653 | ENST00000375715 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| intron-5UTR | ENST00000464653 | ENST00000375708 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
| intron-5UTR | ENST00000464653 | ENST00000550066 | FANCC | chr9 | 98002931 | - | ROR2 | chr9 | 94538100 | - |
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FusionProtFeatures for FANCC_ROR2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FANCC | ROR2 |