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Fusion gene ID: 12911 |
FusionGeneSummary for FANCC_ACOT11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FANCC_ACOT11 | Fusion gene ID: 12911 | Hgene | Tgene | Gene symbol | FANCC | ACOT11 | Gene ID | 2176 | 26027 |
| Gene name | FA complementation group C | acyl-CoA thioesterase 11 | |
| Synonyms | FA3|FAC|FACC | BFIT|STARD14|THEA|THEM1 | |
| Cytomap | 9q22.32 | 1p32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | Fanconi anemia group C proteinFanconi anemia complementation group C | acyl-coenzyme A thioesterase 11START domain containing 14StAR-related lipid transfer (START) domain containing 14acyl-CoA thioester hydrolase 11adipose-associated thioesterasebrown fat-inducible thioesterasethioesterase superfamily member 1thioeste | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q00597 | Q8WXI4 | |
| Ensembl transtripts involved in fusion gene | ENST00000289081, ENST00000375305, ENST00000464653, | ENST00000481208, ENST00000343744, ENST00000371316, | |
| Fusion gene scores | * DoF score | 7 X 5 X 6=210 | 3 X 3 X 2=18 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FANCC [Title/Abstract] AND ACOT11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-IQ-A61I-01A | FANCC | chr9 | 97897628 | - | ACOT11 | chr1 | 55050328 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000289081 | ENST00000481208 | FANCC | chr9 | 97897628 | - | ACOT11 | chr1 | 55050328 | + |
| 5CDS-3UTR | ENST00000289081 | ENST00000343744 | FANCC | chr9 | 97897628 | - | ACOT11 | chr1 | 55050328 | + |
| 5CDS-3UTR | ENST00000289081 | ENST00000371316 | FANCC | chr9 | 97897628 | - | ACOT11 | chr1 | 55050328 | + |
| 5CDS-3UTR | ENST00000375305 | ENST00000481208 | FANCC | chr9 | 97897628 | - | ACOT11 | chr1 | 55050328 | + |
| 5CDS-3UTR | ENST00000375305 | ENST00000343744 | FANCC | chr9 | 97897628 | - | ACOT11 | chr1 | 55050328 | + |
| 5CDS-3UTR | ENST00000375305 | ENST00000371316 | FANCC | chr9 | 97897628 | - | ACOT11 | chr1 | 55050328 | + |
| intron-3UTR | ENST00000464653 | ENST00000481208 | FANCC | chr9 | 97897628 | - | ACOT11 | chr1 | 55050328 | + |
| intron-3UTR | ENST00000464653 | ENST00000343744 | FANCC | chr9 | 97897628 | - | ACOT11 | chr1 | 55050328 | + |
| intron-3UTR | ENST00000464653 | ENST00000371316 | FANCC | chr9 | 97897628 | - | ACOT11 | chr1 | 55050328 | + |
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FusionProtFeatures for FANCC_ACOT11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FANCC | ACOT11 |