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Fusion gene ID: 12808 |
FusionGeneSummary for FAM49B_AK5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAM49B_AK5 | Fusion gene ID: 12808 | Hgene | Tgene | Gene symbol | FAM49B | AK5 | Gene ID | 51571 | 26289 |
| Gene name | family with sequence similarity 49 member B | adenylate kinase 5 | |
| Synonyms | BM-009|L1 | AK6 | |
| Cytomap | 8q24.21 | 1p31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein FAM49BFAM49B/JPH1 fusionMTSS1/FAM49B fusion | adenylate kinase isoenzyme 5AK 5ATP-AMP transphosphorylase 5adenylate kinase 6 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9NUQ9 | Q9Y6K8 | |
| Ensembl transtripts involved in fusion gene | ENST00000519824, ENST00000522746, ENST00000523509, ENST00000401979, ENST00000519110, ENST00000522250, ENST00000517654, ENST00000519540, ENST00000522941, ENST00000518879, | ENST00000354567, ENST00000344720, ENST00000317704, ENST00000478255, | |
| Fusion gene scores | * DoF score | 13 X 9 X 11=1287 | 5 X 3 X 4=60 |
| # samples | 16 | 5 | |
| ** MAII score | log2(16/1287*10)=-3.00786824333334 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FAM49B [Title/Abstract] AND AK5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | AK5 | GO:0006165 | nucleoside diphosphate phosphorylation | 23416111 |
| Tgene | AK5 | GO:0009142 | nucleoside triphosphate biosynthetic process | 23416111 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-DK-A3IM-01A | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000519824 | ENST00000354567 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-3CDS | ENST00000519824 | ENST00000344720 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000519824 | ENST00000317704 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000519824 | ENST00000478255 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-3CDS | ENST00000522746 | ENST00000354567 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-3CDS | ENST00000522746 | ENST00000344720 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000522746 | ENST00000317704 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000522746 | ENST00000478255 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-3CDS | ENST00000523509 | ENST00000354567 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-3CDS | ENST00000523509 | ENST00000344720 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000523509 | ENST00000317704 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000523509 | ENST00000478255 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-3CDS | ENST00000401979 | ENST00000354567 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-3CDS | ENST00000401979 | ENST00000344720 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000401979 | ENST00000317704 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000401979 | ENST00000478255 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-3CDS | ENST00000519110 | ENST00000354567 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-3CDS | ENST00000519110 | ENST00000344720 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000519110 | ENST00000317704 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000519110 | ENST00000478255 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| intron-3CDS | ENST00000522250 | ENST00000354567 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| intron-3CDS | ENST00000522250 | ENST00000344720 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| intron-intron | ENST00000522250 | ENST00000317704 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| intron-intron | ENST00000522250 | ENST00000478255 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-3CDS | ENST00000517654 | ENST00000354567 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-3CDS | ENST00000517654 | ENST00000344720 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000517654 | ENST00000317704 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000517654 | ENST00000478255 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-3CDS | ENST00000519540 | ENST00000354567 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-3CDS | ENST00000519540 | ENST00000344720 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000519540 | ENST00000317704 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000519540 | ENST00000478255 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-3CDS | ENST00000522941 | ENST00000354567 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-3CDS | ENST00000522941 | ENST00000344720 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000522941 | ENST00000317704 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000522941 | ENST00000478255 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-3CDS | ENST00000518879 | ENST00000354567 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-3CDS | ENST00000518879 | ENST00000344720 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000518879 | ENST00000317704 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
| 5UTR-intron | ENST00000518879 | ENST00000478255 | FAM49B | chr8 | 130915558 | - | AK5 | chr1 | 77949002 | + |
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FusionProtFeatures for FAM49B_AK5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FAM49B | AK5 |