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Fusion gene ID: 12781 |
FusionGeneSummary for FAM222B_STXBP4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAM222B_STXBP4 | Fusion gene ID: 12781 | Hgene | Tgene | Gene symbol | FAM222B | STXBP4 | Gene ID | 55731 | 252983 |
| Gene name | family with sequence similarity 222 member B | syntaxin binding protein 4 | |
| Synonyms | C17orf63 | Synip | |
| Cytomap | 17q11.2 | 17q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein FAM222Buncharacterized protein C17orf63 | syntaxin-binding protein 4STX4-interacting proteinsyntaxin 4 interacting protein | |
| Modification date | 20180519 | 20180520 | |
| UniProtAcc | Q8WU58 | Q6ZWJ1 | |
| Ensembl transtripts involved in fusion gene | ENST00000341217, ENST00000581407, ENST00000582266, ENST00000452648, ENST00000582059, ENST00000583953, ENST00000577682, ENST00000583522, ENST00000581381, | ENST00000299341, ENST00000376352, ENST00000405898, ENST00000434978, ENST00000398391, | |
| Fusion gene scores | * DoF score | 19 X 7 X 13=1729 | 8 X 5 X 5=200 |
| # samples | 22 | 7 | |
| ** MAII score | log2(22/1729*10)=-2.97436244011762 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/200*10)=-1.51457317282976 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FAM222B [Title/Abstract] AND STXBP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | STXBP4 | GO:0006974 | cellular response to DNA damage stimulus | 19451233 |
| Tgene | STXBP4 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus | 12855681 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | READ | TCGA-AG-3731-01A | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000341217 | ENST00000299341 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000341217 | ENST00000376352 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000341217 | ENST00000405898 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000341217 | ENST00000434978 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000341217 | ENST00000398391 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000581407 | ENST00000299341 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000581407 | ENST00000376352 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000581407 | ENST00000405898 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000581407 | ENST00000434978 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000581407 | ENST00000398391 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000582266 | ENST00000299341 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000582266 | ENST00000376352 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000582266 | ENST00000405898 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000582266 | ENST00000434978 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000582266 | ENST00000398391 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| 5UTR-5UTR | ENST00000452648 | ENST00000299341 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| 5UTR-5UTR | ENST00000452648 | ENST00000376352 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| 5UTR-5UTR | ENST00000452648 | ENST00000405898 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| 5UTR-5UTR | ENST00000452648 | ENST00000434978 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| 5UTR-5UTR | ENST00000452648 | ENST00000398391 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000582059 | ENST00000299341 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000582059 | ENST00000376352 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000582059 | ENST00000405898 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000582059 | ENST00000434978 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000582059 | ENST00000398391 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000583953 | ENST00000299341 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000583953 | ENST00000376352 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000583953 | ENST00000405898 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000583953 | ENST00000434978 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000583953 | ENST00000398391 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000577682 | ENST00000299341 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000577682 | ENST00000376352 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000577682 | ENST00000405898 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000577682 | ENST00000434978 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000577682 | ENST00000398391 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000583522 | ENST00000299341 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000583522 | ENST00000376352 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000583522 | ENST00000405898 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000583522 | ENST00000434978 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000583522 | ENST00000398391 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000581381 | ENST00000299341 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000581381 | ENST00000376352 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000581381 | ENST00000405898 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000581381 | ENST00000434978 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
| intron-5UTR | ENST00000581381 | ENST00000398391 | FAM222B | chr17 | 27139227 | - | STXBP4 | chr17 | 53076706 | + |
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FusionProtFeatures for FAM222B_STXBP4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FAM222B | STXBP4 |