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Fusion gene ID: 12779 |
FusionGeneSummary for FAM222B_PRPSAP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAM222B_PRPSAP1 | Fusion gene ID: 12779 | Hgene | Tgene | Gene symbol | FAM222B | PRPSAP1 | Gene ID | 55731 | 5635 |
| Gene name | family with sequence similarity 222 member B | phosphoribosyl pyrophosphate synthetase associated protein 1 | |
| Synonyms | C17orf63 | PAP39 | |
| Cytomap | 17q11.2 | 17q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein FAM222Buncharacterized protein C17orf63 | phosphoribosyl pyrophosphate synthase-associated protein 139 kDa phosphoribosypyrophosphate synthase-associated proteinPRPP synthase-associated protein 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8WU58 | Q14558 | |
| Ensembl transtripts involved in fusion gene | ENST00000341217, ENST00000581407, ENST00000582266, ENST00000452648, ENST00000582059, ENST00000583953, ENST00000577682, ENST00000583522, ENST00000581381, | ENST00000446526, ENST00000324684, ENST00000588364, | |
| Fusion gene scores | * DoF score | 19 X 7 X 13=1729 | 2 X 1 X 3=6 |
| # samples | 22 | 3 | |
| ** MAII score | log2(22/1729*10)=-2.97436244011762 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/6*10)=2.32192809488736 | |
| Context | PubMed: FAM222B [Title/Abstract] AND PRPSAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-X6-A7W8-01A | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000341217 | ENST00000446526 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| intron-3CDS | ENST00000341217 | ENST00000324684 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| intron-intron | ENST00000341217 | ENST00000588364 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| 5UTR-3CDS | ENST00000581407 | ENST00000446526 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| 5UTR-3CDS | ENST00000581407 | ENST00000324684 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| 5UTR-intron | ENST00000581407 | ENST00000588364 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| 5UTR-3CDS | ENST00000582266 | ENST00000446526 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| 5UTR-3CDS | ENST00000582266 | ENST00000324684 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| 5UTR-intron | ENST00000582266 | ENST00000588364 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| intron-3CDS | ENST00000452648 | ENST00000446526 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| intron-3CDS | ENST00000452648 | ENST00000324684 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| intron-intron | ENST00000452648 | ENST00000588364 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| intron-3CDS | ENST00000582059 | ENST00000446526 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| intron-3CDS | ENST00000582059 | ENST00000324684 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| intron-intron | ENST00000582059 | ENST00000588364 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| intron-3CDS | ENST00000583953 | ENST00000446526 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| intron-3CDS | ENST00000583953 | ENST00000324684 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| intron-intron | ENST00000583953 | ENST00000588364 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| 5UTR-3CDS | ENST00000577682 | ENST00000446526 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| 5UTR-3CDS | ENST00000577682 | ENST00000324684 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| 5UTR-intron | ENST00000577682 | ENST00000588364 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| 5UTR-3CDS | ENST00000583522 | ENST00000446526 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| 5UTR-3CDS | ENST00000583522 | ENST00000324684 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| 5UTR-intron | ENST00000583522 | ENST00000588364 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| 5UTR-3CDS | ENST00000581381 | ENST00000446526 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| 5UTR-3CDS | ENST00000581381 | ENST00000324684 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
| 5UTR-intron | ENST00000581381 | ENST00000588364 | FAM222B | chr17 | 27169700 | - | PRPSAP1 | chr17 | 74309972 | - |
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FusionProtFeatures for FAM222B_PRPSAP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FAM222B | PRPSAP1 |