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Fusion gene ID: 12761 |
FusionGeneSummary for FAM219A_POLN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAM219A_POLN | Fusion gene ID: 12761 | Hgene | Tgene | Gene symbol | FAM219A | POLN | Gene ID | 203259 | 353497 |
| Gene name | family with sequence similarity 219 member A | DNA polymerase nu | |
| Synonyms | C9orf25 | POL4P | |
| Cytomap | 9p13.3 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein FAM219Auncharacterized protein C9orf25 | DNA polymerase nuDNA polymerase NDNA polymerase POL4Ppolymerase (DNA directed) nupolymerase (DNA) nu | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IW50 | Q7Z5Q5 | |
| Ensembl transtripts involved in fusion gene | ENST00000379081, ENST00000379087, ENST00000379080, ENST00000379084, ENST00000379089, ENST00000445726, ENST00000297620, ENST00000379078, | ENST00000382865, ENST00000511885, ENST00000515357, | |
| Fusion gene scores | * DoF score | 6 X 4 X 4=96 | 12 X 7 X 9=756 |
| # samples | 7 | 12 | |
| ** MAII score | log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/756*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FAM219A [Title/Abstract] AND POLN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | POLN | GO:0019985 | translesion synthesis | 20102227 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-06-0744-01A | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000379081 | ENST00000382865 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| intron-3CDS | ENST00000379081 | ENST00000511885 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| intron-intron | ENST00000379081 | ENST00000515357 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| Frame-shift | ENST00000379087 | ENST00000382865 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| Frame-shift | ENST00000379087 | ENST00000511885 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| 5CDS-intron | ENST00000379087 | ENST00000515357 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| intron-3CDS | ENST00000379080 | ENST00000382865 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| intron-3CDS | ENST00000379080 | ENST00000511885 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| intron-intron | ENST00000379080 | ENST00000515357 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| Frame-shift | ENST00000379084 | ENST00000382865 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| Frame-shift | ENST00000379084 | ENST00000511885 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| 5CDS-intron | ENST00000379084 | ENST00000515357 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| Frame-shift | ENST00000379089 | ENST00000382865 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| Frame-shift | ENST00000379089 | ENST00000511885 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| 5CDS-intron | ENST00000379089 | ENST00000515357 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| Frame-shift | ENST00000445726 | ENST00000382865 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| Frame-shift | ENST00000445726 | ENST00000511885 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| 5CDS-intron | ENST00000445726 | ENST00000515357 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| Frame-shift | ENST00000297620 | ENST00000382865 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| Frame-shift | ENST00000297620 | ENST00000511885 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| 5CDS-intron | ENST00000297620 | ENST00000515357 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| Frame-shift | ENST00000379078 | ENST00000382865 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| Frame-shift | ENST00000379078 | ENST00000511885 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
| 5CDS-intron | ENST00000379078 | ENST00000515357 | FAM219A | chr9 | 34458202 | - | POLN | chr4 | 2097660 | - |
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FusionProtFeatures for FAM219A_POLN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FAM219A | POLN |