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Fusion gene ID: 12687

FusionGeneSummary for FAM193A_RGS12

Fusion gene summary

Fusion gene information	Fusion gene name: FAM193A_RGS12
	Fusion gene ID: 12687
		Hgene	Tgene
	Gene symbol	FAM193A	RGS12
	Gene ID	8603	6002
	Gene name	family with sequence similarity 193 member A	regulator of G protein signaling 12
	Synonyms	C4orf8\|RES4-22	-
	Cytomap	4p16.3	4p16.3
	Type of gene	protein-coding	protein-coding
	Description	protein FAM193A	regulator of G-protein signaling 12regulator of G-protein signalling 12
	Modification date	20180519	20180519
	UniProtAcc	P78312	O14924
	Ensembl transtripts involved in fusion gene	ENST00000545951, ENST00000382839, ENST00000324666, ENST00000502458, ENST00000505311,	ENST00000543385, ENST00000336727, ENST00000344733, ENST00000382788, ENST00000306648, ENST00000338806, ENST00000508158, ENST00000538395,
Fusion gene scores	* DoF score	10 X 8 X 8=640	4 X 5 X 3=60
	# samples	11	7
	** MAII score	log2(11/640*10)=-2.5405683813627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/60*10)=0.222392421336448 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: FAM193A [Title/Abstract] AND RGS12 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	THYM	TCGA-ZB-A969-01A	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000545951	ENST00000543385	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000545951	ENST00000336727	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000545951	ENST00000344733	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000545951	ENST00000382788	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000545951	ENST00000306648	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000545951	ENST00000338806	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
5CDS-3UTR	ENST00000545951	ENST00000508158	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
5CDS-3UTR	ENST00000545951	ENST00000538395	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000382839	ENST00000543385	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000382839	ENST00000336727	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000382839	ENST00000344733	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000382839	ENST00000382788	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000382839	ENST00000306648	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000382839	ENST00000338806	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
5CDS-3UTR	ENST00000382839	ENST00000508158	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
5CDS-3UTR	ENST00000382839	ENST00000538395	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000324666	ENST00000543385	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000324666	ENST00000336727	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000324666	ENST00000344733	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000324666	ENST00000382788	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000324666	ENST00000306648	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000324666	ENST00000338806	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
5CDS-3UTR	ENST00000324666	ENST00000508158	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
5CDS-3UTR	ENST00000324666	ENST00000538395	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000502458	ENST00000543385	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000502458	ENST00000336727	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000502458	ENST00000344733	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000502458	ENST00000382788	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000502458	ENST00000306648	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000502458	ENST00000338806	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
5CDS-3UTR	ENST00000502458	ENST00000508158	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
5CDS-3UTR	ENST00000502458	ENST00000538395	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000505311	ENST00000543385	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000505311	ENST00000336727	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000505311	ENST00000344733	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000505311	ENST00000382788	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000505311	ENST00000306648	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
Frame-shift	ENST00000505311	ENST00000338806	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
5CDS-3UTR	ENST00000505311	ENST00000508158	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+
5CDS-3UTR	ENST00000505311	ENST00000538395	FAM193A	chr4	2641586	+	RGS12	chr4	3415799	+

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FusionProtFeatures for FAM193A_RGS12

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FAM193A P78312	RGS12 O14924

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Fusion gene ID: 12687

FusionGeneSummary for FAM193A_RGS12

FusionProtFeatures for FAM193A_RGS12