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Fusion gene ID: 12686

FusionGeneSummary for FAM193A_PPP2R2C

Fusion gene summary

Fusion gene information	Fusion gene name: FAM193A_PPP2R2C
	Fusion gene ID: 12686
		Hgene	Tgene
	Gene symbol	FAM193A	PPP2R2C
	Gene ID	8603	5522
	Gene name	family with sequence similarity 193 member A	protein phosphatase 2 regulatory subunit Bgamma
	Synonyms	C4orf8\|RES4-22	B55-GAMMA\|B55gamma\|IMYPNO\|IMYPNO1\|PR52\|PR55G
	Cytomap	4p16.3	4p16.1
	Type of gene	protein-coding	protein-coding
	Description	protein FAM193A	protein phosphatase 2, regulatory subunit B, gammaPP2A, subunit B, B-gamma isoformPP2A, subunit B, B55-gamma isoformPP2A, subunit B, PR55-gamma isoformPP2A, subunit B, R2-gamma isoformgamma isoform of regulatory subunit B55, protein phosphatase 2pho
	Modification date	20180519	20180527
	UniProtAcc	P78312	Q9Y2T4
	Ensembl transtripts involved in fusion gene	ENST00000545951, ENST00000382839, ENST00000324666, ENST00000502458, ENST00000505311,	ENST00000506140, ENST00000515571, ENST00000382599, ENST00000507294, ENST00000314348, ENST00000335585,
Fusion gene scores	* DoF score	10 X 8 X 8=640	4 X 5 X 4=80
	# samples	11	5
	** MAII score	log2(11/640*10)=-2.5405683813627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FAM193A [Title/Abstract] AND PPP2R2C [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LGG	TCGA-DH-A669-02A	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
TCGA	RV	LGG	TCGA-DH-A669-01A	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000545951	ENST00000506140	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000545951	ENST00000515571	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000545951	ENST00000382599	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000545951	ENST00000507294	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
5CDS-intron	ENST00000545951	ENST00000314348	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
5CDS-intron	ENST00000545951	ENST00000335585	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000382839	ENST00000506140	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000382839	ENST00000515571	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000382839	ENST00000382599	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000382839	ENST00000507294	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
5CDS-intron	ENST00000382839	ENST00000314348	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
5CDS-intron	ENST00000382839	ENST00000335585	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000324666	ENST00000506140	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000324666	ENST00000515571	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000324666	ENST00000382599	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000324666	ENST00000507294	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
5CDS-intron	ENST00000324666	ENST00000314348	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
5CDS-intron	ENST00000324666	ENST00000335585	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000502458	ENST00000506140	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000502458	ENST00000515571	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000502458	ENST00000382599	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000502458	ENST00000507294	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
5CDS-intron	ENST00000502458	ENST00000314348	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
5CDS-intron	ENST00000502458	ENST00000335585	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000505311	ENST00000506140	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000505311	ENST00000515571	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000505311	ENST00000382599	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
Frame-shift	ENST00000505311	ENST00000507294	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
5CDS-intron	ENST00000505311	ENST00000314348	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-
5CDS-intron	ENST00000505311	ENST00000335585	FAM193A	chr4	2632896	+	PPP2R2C	chr4	6335458	-

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FusionProtFeatures for FAM193A_PPP2R2C

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FAM193A P78312	PPP2R2C Q9Y2T4

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Fusion gene ID: 12686

FusionGeneSummary for FAM193A_PPP2R2C

FusionProtFeatures for FAM193A_PPP2R2C