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Fusion gene ID: 12665

FusionGeneSummary for FAM178B_PRRG1

Fusion gene summary

Fusion gene information	Fusion gene name: FAM178B_PRRG1
	Fusion gene ID: 12665
		Hgene	Tgene
	Gene symbol	FAM178B	PRRG1
	Gene ID	51252	5638
	Gene name	family with sequence similarity 178 member B	proline rich and Gla domain 1
	Synonyms	-	PRGP1
	Cytomap	2q11.2	Xp21.1
	Type of gene	protein-coding	protein-coding
	Description	protein FAM178B	transmembrane gamma-carboxyglutamic acid protein 1proline rich Gla (G-carboxyglutamic acid) 1proline-rich Gla (G-carboxyglutamic acid) polypeptide 1
	Modification date	20180519	20180519
	UniProtAcc	Q8IXR5	O14668
	Ensembl transtripts involved in fusion gene	ENST00000327896, ENST00000417561, ENST00000490605, ENST00000393526, ENST00000470789,	ENST00000378628, ENST00000491253, ENST00000543642, ENST00000542554, ENST00000449135, ENST00000463135,
Fusion gene scores	* DoF score	2 X 2 X 1=4	1 X 1 X 1=1
	# samples	2	1
	** MAII score	log2(2/4*10)=2.32192809488736	log2(1/1*10)=3.32192809488736
Context	PubMed: FAM178B [Title/Abstract] AND PRRG1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BQ226718	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-intron	ENST00000327896	ENST00000378628	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
5UTR-intron	ENST00000327896	ENST00000491253	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
5UTR-intron	ENST00000327896	ENST00000543642	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
5UTR-5UTR	ENST00000327896	ENST00000542554	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
5UTR-5UTR	ENST00000327896	ENST00000449135	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
5UTR-intron	ENST00000327896	ENST00000463135	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-intron	ENST00000417561	ENST00000378628	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-intron	ENST00000417561	ENST00000491253	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-intron	ENST00000417561	ENST00000543642	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-5UTR	ENST00000417561	ENST00000542554	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-5UTR	ENST00000417561	ENST00000449135	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-intron	ENST00000417561	ENST00000463135	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
5CDS-intron	ENST00000490605	ENST00000378628	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
5CDS-intron	ENST00000490605	ENST00000491253	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
5CDS-intron	ENST00000490605	ENST00000543642	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
5CDS-5UTR	ENST00000490605	ENST00000542554	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
5CDS-5UTR	ENST00000490605	ENST00000449135	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
5CDS-intron	ENST00000490605	ENST00000463135	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-intron	ENST00000393526	ENST00000378628	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-intron	ENST00000393526	ENST00000491253	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-intron	ENST00000393526	ENST00000543642	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-5UTR	ENST00000393526	ENST00000542554	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-5UTR	ENST00000393526	ENST00000449135	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-intron	ENST00000393526	ENST00000463135	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-intron	ENST00000470789	ENST00000378628	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-intron	ENST00000470789	ENST00000491253	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-intron	ENST00000470789	ENST00000543642	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-5UTR	ENST00000470789	ENST00000542554	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-5UTR	ENST00000470789	ENST00000449135	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+
intron-intron	ENST00000470789	ENST00000463135	FAM178B	chr2	97651977	-	PRRG1	chrX	37245850	+

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FusionProtFeatures for FAM178B_PRRG1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FAM178B Q8IXR5	PRRG1 O14668

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Fusion gene ID: 12665

FusionGeneSummary for FAM178B_PRRG1

FusionProtFeatures for FAM178B_PRRG1