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Fusion gene ID: 12597 |
FusionGeneSummary for FAM160A1_ADAM2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAM160A1_ADAM2 | Fusion gene ID: 12597 | Hgene | Tgene | Gene symbol | FAM160A1 | ADAM2 | Gene ID | 729830 | 2515 |
| Gene name | family with sequence similarity 160 member A1 | ADAM metallopeptidase domain 2 | |
| Synonyms | - | CRYN1|CRYN2|CT15|FTNB|PH-30b|PH30|PH30-beta | |
| Cytomap | 4q31.3 | 8p11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein FAM160A1 | disintegrin and metalloproteinase domain-containing protein 2cancer/testis antigen 15fertilin subunit beta | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q05DH4 | Q99965 | |
| Ensembl transtripts involved in fusion gene | ENST00000508198, ENST00000435205, ENST00000505231, | ENST00000347580, ENST00000379853, ENST00000265708, ENST00000521880, ENST00000523181, | |
| Fusion gene scores | * DoF score | 7 X 5 X 5=175 | 6 X 3 X 3=54 |
| # samples | 8 | 6 | |
| ** MAII score | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/54*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FAM160A1 [Title/Abstract] AND ADAM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | CESC | TCGA-ZJ-AB0I-01A | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000508198 | ENST00000347580 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
| 3UTR-3CDS | ENST00000508198 | ENST00000379853 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
| 3UTR-3CDS | ENST00000508198 | ENST00000265708 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
| 3UTR-3CDS | ENST00000508198 | ENST00000521880 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
| 3UTR-intron | ENST00000508198 | ENST00000523181 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
| 5UTR-3CDS | ENST00000435205 | ENST00000347580 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
| 5UTR-3CDS | ENST00000435205 | ENST00000379853 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
| 5UTR-3CDS | ENST00000435205 | ENST00000265708 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
| 5UTR-3CDS | ENST00000435205 | ENST00000521880 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
| 5UTR-intron | ENST00000435205 | ENST00000523181 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
| intron-3CDS | ENST00000505231 | ENST00000347580 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
| intron-3CDS | ENST00000505231 | ENST00000379853 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
| intron-3CDS | ENST00000505231 | ENST00000265708 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
| intron-3CDS | ENST00000505231 | ENST00000521880 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
| intron-intron | ENST00000505231 | ENST00000523181 | FAM160A1 | chr4 | 152330617 | + | ADAM2 | chr8 | 39627094 | - |
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FusionProtFeatures for FAM160A1_ADAM2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FAM160A1 | ADAM2 |