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Fusion gene ID: 12519 |
FusionGeneSummary for FAM122C_TFDP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAM122C_TFDP1 | Fusion gene ID: 12519 | Hgene | Tgene | Gene symbol | FAM122C | TFDP1 | Gene ID | 159091 | 7027 |
| Gene name | family with sequence similarity 122C | transcription factor Dp-1 | |
| Synonyms | - | DILC|DP1|DRTF1|Dp-1 | |
| Cytomap | Xq26.3 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein FAM122C | transcription factor Dp-1DRTF1-polypeptide 1E2F dimerization partner 1E2F-related transcription factordown-regulated in liver cancer stem cells | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q6P4D5 | Q14186 | |
| Ensembl transtripts involved in fusion gene | ENST00000414371, ENST00000370784, ENST00000370785, ENST00000445123, ENST00000475361, | ENST00000375370, ENST00000538138, ENST00000465174, ENST00000544902, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 4 X 6=144 |
| # samples | 1 | 7 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FAM122C [Title/Abstract] AND TFDP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TFDP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7739537 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF853321 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000414371 | ENST00000375370 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000414371 | ENST00000538138 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000414371 | ENST00000465174 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000414371 | ENST00000544902 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000370784 | ENST00000375370 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000370784 | ENST00000538138 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000370784 | ENST00000465174 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000370784 | ENST00000544902 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000370785 | ENST00000375370 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000370785 | ENST00000538138 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000370785 | ENST00000465174 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000370785 | ENST00000544902 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000445123 | ENST00000375370 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000445123 | ENST00000538138 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000445123 | ENST00000465174 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000445123 | ENST00000544902 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000475361 | ENST00000375370 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000475361 | ENST00000538138 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000475361 | ENST00000465174 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
| intron-intron | ENST00000475361 | ENST00000544902 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
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FusionProtFeatures for FAM122C_TFDP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FAM122C | TFDP1 |