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Fusion gene ID: 1244 |
FusionGeneSummary for AHR_CDK14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AHR_CDK14 | Fusion gene ID: 1244 | Hgene | Tgene | Gene symbol | AHR | CDK14 | Gene ID | 196 | 5218 |
| Gene name | aryl hydrocarbon receptor | cyclin dependent kinase 14 | |
| Synonyms | bHLHe76 | PFTAIRE1|PFTK1 | |
| Cytomap | 7p21.1 | 7q21.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | aryl hydrocarbon receptorAH-receptorah receptoraromatic hydrocarbon receptorclass E basic helix-loop-helix protein 76 | cyclin-dependent kinase 14PFTAIRE protein kinase 1cell division protein kinase 14serine/threonine-protein kinase PFTAIRE-1 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P35869 | O94921 | |
| Ensembl transtripts involved in fusion gene | ENST00000242057, ENST00000492120, | ENST00000380050, ENST00000265741, ENST00000406263, ENST00000436577, ENST00000496279, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 17 X 14 X 9=2142 |
| # samples | 6 | 19 | |
| ** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(19/2142*10)=-3.49488715641931 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AHR [Title/Abstract] AND CDK14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AHR | GO:0006355 | regulation of transcription, DNA-templated | 10395741 |
| Hgene | AHR | GO:0006357 | regulation of transcription by RNA polymerase II | 15681594 |
| Hgene | AHR | GO:0006366 | transcription by RNA polymerase II | 10395741 |
| Hgene | AHR | GO:0009410 | response to xenobiotic stimulus | 7961644 |
| Hgene | AHR | GO:0009636 | response to toxic substance | 7961644 |
| Hgene | AHR | GO:0010468 | regulation of gene expression | 15681594 |
| Hgene | AHR | GO:0019933 | cAMP-mediated signaling | 17329248 |
| Hgene | AHR | GO:0030888 | regulation of B cell proliferation | 15681594 |
| Hgene | AHR | GO:0071320 | cellular response to cAMP | 17329248 |
| Hgene | AHR | GO:1904322 | cellular response to forskolin | 17329248 |
| Hgene | AHR | GO:1904613 | cellular response to 2,3,7,8-tetrachlorodibenzodioxine | 17329248 |
| Tgene | CDK14 | GO:0000086 | G2/M transition of mitotic cell cycle | 20059949 |
| Tgene | CDK14 | GO:0060828 | regulation of canonical Wnt signaling pathway | 20059949 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AN-A0FY-01A | AHR | chr7 | 17338953 | + | CDK14 | chr7 | 90741857 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000242057 | ENST00000380050 | AHR | chr7 | 17338953 | + | CDK14 | chr7 | 90741857 | + |
| In-frame | ENST00000242057 | ENST00000265741 | AHR | chr7 | 17338953 | + | CDK14 | chr7 | 90741857 | + |
| In-frame | ENST00000242057 | ENST00000406263 | AHR | chr7 | 17338953 | + | CDK14 | chr7 | 90741857 | + |
| In-frame | ENST00000242057 | ENST00000436577 | AHR | chr7 | 17338953 | + | CDK14 | chr7 | 90741857 | + |
| 5CDS-intron | ENST00000242057 | ENST00000496279 | AHR | chr7 | 17338953 | + | CDK14 | chr7 | 90741857 | + |
| intron-3CDS | ENST00000492120 | ENST00000380050 | AHR | chr7 | 17338953 | + | CDK14 | chr7 | 90741857 | + |
| intron-3CDS | ENST00000492120 | ENST00000265741 | AHR | chr7 | 17338953 | + | CDK14 | chr7 | 90741857 | + |
| intron-3CDS | ENST00000492120 | ENST00000406263 | AHR | chr7 | 17338953 | + | CDK14 | chr7 | 90741857 | + |
| intron-3CDS | ENST00000492120 | ENST00000436577 | AHR | chr7 | 17338953 | + | CDK14 | chr7 | 90741857 | + |
| intron-intron | ENST00000492120 | ENST00000496279 | AHR | chr7 | 17338953 | + | CDK14 | chr7 | 90741857 | + |
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FusionProtFeatures for AHR_CDK14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AHR | CDK14 |