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Fusion gene ID: 12401 |
FusionGeneSummary for F3_C1orf21 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: F3_C1orf21 | Fusion gene ID: 12401 | Hgene | Tgene | Gene symbol | F3 | C1orf21 | Gene ID | 2152 | 81563 |
| Gene name | coagulation factor III, tissue factor | chromosome 1 open reading frame 21 | |
| Synonyms | CD142|TF|TFA | PIG13 | |
| Cytomap | 1p21.3 | 1q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tissue factorcoagulation factor III (thromboplastin, tissue factor) | uncharacterized protein C1orf21cell proliferation-inducing gene 13 proteinproliferation-inducing protein 13 | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | P13726 | Q9H246 | |
| Ensembl transtripts involved in fusion gene | ENST00000334047, ENST00000370207, ENST00000480356, | ENST00000235307, ENST00000367514, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 4 X 3 X 4=48 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: F3 [Title/Abstract] AND C1orf21 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | F3 | GO:0001938 | positive regulation of endothelial cell proliferation | 17898544 |
| Hgene | F3 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response | 17469850 |
| Hgene | F3 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 17898544 |
| Hgene | F3 | GO:0007596 | blood coagulation | 8632006|24998411 |
| Hgene | F3 | GO:0010641 | positive regulation of platelet-derived growth factor receptor signaling pathway | 17991872 |
| Hgene | F3 | GO:0016485 | protein processing | 24998411 |
| Hgene | F3 | GO:0045766 | positive regulation of angiogenesis | 17898544 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI624522 | F3 | chr1 | 94999474 | + | C1orf21 | chr1 | 184484981 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000334047 | ENST00000235307 | F3 | chr1 | 94999474 | + | C1orf21 | chr1 | 184484981 | - |
| intron-intron | ENST00000334047 | ENST00000367514 | F3 | chr1 | 94999474 | + | C1orf21 | chr1 | 184484981 | - |
| intron-intron | ENST00000370207 | ENST00000235307 | F3 | chr1 | 94999474 | + | C1orf21 | chr1 | 184484981 | - |
| intron-intron | ENST00000370207 | ENST00000367514 | F3 | chr1 | 94999474 | + | C1orf21 | chr1 | 184484981 | - |
| intron-intron | ENST00000480356 | ENST00000235307 | F3 | chr1 | 94999474 | + | C1orf21 | chr1 | 184484981 | - |
| intron-intron | ENST00000480356 | ENST00000367514 | F3 | chr1 | 94999474 | + | C1orf21 | chr1 | 184484981 | - |
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FusionProtFeatures for F3_C1orf21 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| F3 | C1orf21 |