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Fusion gene ID: 12352 |
FusionGeneSummary for EYA3_TMEM61 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EYA3_TMEM61 | Fusion gene ID: 12352 | Hgene | Tgene | Gene symbol | EYA3 | TMEM61 | Gene ID | 2140 | 199964 |
| Gene name | EYA transcriptional coactivator and phosphatase 3 | transmembrane protein 61 | |
| Synonyms | - | - | |
| Cytomap | 1p35.3 | 1p32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eyes absent homolog 3eyes absent 3 | transmembrane protein 61 | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | Q99504 | Q8N0U2 | |
| Ensembl transtripts involved in fusion gene | ENST00000373871, ENST00000436342, ENST00000373864, ENST00000540618, ENST00000545175, ENST00000373863, ENST00000471498, | ENST00000371268, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 2 X 1 X 2=4 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/60*10)=0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: EYA3 [Title/Abstract] AND TMEM61 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EYA3 | GO:0010212 | response to ionizing radiation | 19234442 |
| Hgene | EYA3 | GO:0016576 | histone dephosphorylation | 19234442|19351884 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-FP-7829-01A | EYA3 | chr1 | 28415035 | - | TMEM61 | chr1 | 55457509 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000373871 | ENST00000371268 | EYA3 | chr1 | 28415035 | - | TMEM61 | chr1 | 55457509 | + |
| 5UTR-3CDS | ENST00000436342 | ENST00000371268 | EYA3 | chr1 | 28415035 | - | TMEM61 | chr1 | 55457509 | + |
| intron-3CDS | ENST00000373864 | ENST00000371268 | EYA3 | chr1 | 28415035 | - | TMEM61 | chr1 | 55457509 | + |
| 5UTR-3CDS | ENST00000540618 | ENST00000371268 | EYA3 | chr1 | 28415035 | - | TMEM61 | chr1 | 55457509 | + |
| 5UTR-3CDS | ENST00000545175 | ENST00000371268 | EYA3 | chr1 | 28415035 | - | TMEM61 | chr1 | 55457509 | + |
| 5UTR-3CDS | ENST00000373863 | ENST00000371268 | EYA3 | chr1 | 28415035 | - | TMEM61 | chr1 | 55457509 | + |
| 5UTR-3CDS | ENST00000471498 | ENST00000371268 | EYA3 | chr1 | 28415035 | - | TMEM61 | chr1 | 55457509 | + |
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FusionProtFeatures for EYA3_TMEM61 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EYA3 | TMEM61 |