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Fusion gene ID: 12319 |
FusionGeneSummary for EXOSC9_MAPK10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EXOSC9_MAPK10 | Fusion gene ID: 12319 | Hgene | Tgene | Gene symbol | EXOSC9 | MAPK10 | Gene ID | 5393 | 5602 |
| Gene name | exosome component 9 | mitogen-activated protein kinase 10 | |
| Synonyms | PM/Scl-75|PMSCL1|RRP45|Rrp45p|p5|p6 | JNK3|JNK3A|PRKM10|SAPK1b|p493F12|p54bSAPK | |
| Cytomap | 4q27 | 4q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | exosome complex component RRP45P75 polymyositis-scleroderma overlap syndrome associated autoantigenPMSCL autoantigen, 75kDautoantigen PM/Scl 1exosome complex exonuclease RRP45polymyositis/scleroderma autoantigen 1, 75kDa | mitogen-activated protein kinase 10JNK3 alpha protein kinaseMAP kinase 10MAP kinase p49 3F12c-Jun N-terminal kinase 3stress activated protein kinase betastress-activated protein kinase 1bstress-activated protein kinase JNK3 | |
| Modification date | 20180523 | 20180524 | |
| UniProtAcc | Q06265 | P53779 | |
| Ensembl transtripts involved in fusion gene | ENST00000243498, ENST00000509980, ENST00000379663, ENST00000512454, | ENST00000395169, ENST00000359221, ENST00000361569, ENST00000395166, ENST00000449047, ENST00000395161, ENST00000513839, ENST00000395157, ENST00000395160, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 5 X 6=150 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EXOSC9 [Title/Abstract] AND MAPK10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-2Y-A9GZ-01A | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000243498 | ENST00000395169 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| Frame-shift | ENST00000243498 | ENST00000359221 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| Frame-shift | ENST00000243498 | ENST00000361569 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| Frame-shift | ENST00000243498 | ENST00000395166 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| Frame-shift | ENST00000243498 | ENST00000449047 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| Frame-shift | ENST00000243498 | ENST00000395161 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 5CDS-intron | ENST00000243498 | ENST00000513839 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 5CDS-intron | ENST00000243498 | ENST00000395157 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 5CDS-intron | ENST00000243498 | ENST00000395160 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 3UTR-3CDS | ENST00000509980 | ENST00000395169 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 3UTR-3CDS | ENST00000509980 | ENST00000359221 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 3UTR-3CDS | ENST00000509980 | ENST00000361569 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 3UTR-3CDS | ENST00000509980 | ENST00000395166 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 3UTR-3CDS | ENST00000509980 | ENST00000449047 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 3UTR-3CDS | ENST00000509980 | ENST00000395161 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 3UTR-intron | ENST00000509980 | ENST00000513839 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 3UTR-intron | ENST00000509980 | ENST00000395157 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 3UTR-intron | ENST00000509980 | ENST00000395160 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| Frame-shift | ENST00000379663 | ENST00000395169 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| Frame-shift | ENST00000379663 | ENST00000359221 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| Frame-shift | ENST00000379663 | ENST00000361569 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| Frame-shift | ENST00000379663 | ENST00000395166 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| Frame-shift | ENST00000379663 | ENST00000449047 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| Frame-shift | ENST00000379663 | ENST00000395161 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 5CDS-intron | ENST00000379663 | ENST00000513839 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 5CDS-intron | ENST00000379663 | ENST00000395157 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 5CDS-intron | ENST00000379663 | ENST00000395160 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| Frame-shift | ENST00000512454 | ENST00000395169 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| Frame-shift | ENST00000512454 | ENST00000359221 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| Frame-shift | ENST00000512454 | ENST00000361569 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| Frame-shift | ENST00000512454 | ENST00000395166 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| Frame-shift | ENST00000512454 | ENST00000449047 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| Frame-shift | ENST00000512454 | ENST00000395161 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 5CDS-intron | ENST00000512454 | ENST00000513839 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 5CDS-intron | ENST00000512454 | ENST00000395157 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
| 5CDS-intron | ENST00000512454 | ENST00000395160 | EXOSC9 | chr4 | 122728777 | + | MAPK10 | chr4 | 86952584 | - |
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FusionProtFeatures for EXOSC9_MAPK10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EXOSC9 | MAPK10 |