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Fusion gene ID: 12310 |
FusionGeneSummary for EXOSC2_EXOSC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EXOSC2_EXOSC2 | Fusion gene ID: 12310 | Hgene | Tgene | Gene symbol | EXOSC2 | EXOSC2 | Gene ID | 23404 | 23404 |
| Gene name | exosome component 2 | exosome component 2 | |
| Synonyms | RRP4|Rrp4p|SHRF|hRrp4p|p7 | RRP4|Rrp4p|SHRF|hRrp4p|p7 | |
| Cytomap | 9q34.12 | 9q34.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | exosome complex component RRP4exosome complex exonuclease RRP4homolog of yeast RRP4 (ribosomal RNA processing 4), 3' 5' exoribonuclease (RRP4)homolog of yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonucleaseribosomal RNA-processing protein 4 | exosome complex component RRP4exosome complex exonuclease RRP4homolog of yeast RRP4 (ribosomal RNA processing 4), 3' 5' exoribonuclease (RRP4)homolog of yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonucleaseribosomal RNA-processing protein 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q13868 | Q13868 | |
| Ensembl transtripts involved in fusion gene | ENST00000372358, ENST00000546165, ENST00000372352, ENST00000372351, ENST00000467138, | ENST00000372358, ENST00000546165, ENST00000372352, ENST00000372351, ENST00000467138, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 3=27 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: EXOSC2 [Title/Abstract] AND EXOSC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF155556 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000372358 | ENST00000372358 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000372358 | ENST00000546165 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000372358 | ENST00000372352 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000372358 | ENST00000372351 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000372358 | ENST00000467138 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000546165 | ENST00000372358 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000546165 | ENST00000546165 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000546165 | ENST00000372352 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000546165 | ENST00000372351 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000546165 | ENST00000467138 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000372352 | ENST00000372358 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000372352 | ENST00000546165 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000372352 | ENST00000372352 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000372352 | ENST00000372351 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000372352 | ENST00000467138 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000372351 | ENST00000372358 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000372351 | ENST00000546165 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000372351 | ENST00000372352 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000372351 | ENST00000372351 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000372351 | ENST00000467138 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000467138 | ENST00000372358 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000467138 | ENST00000546165 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000467138 | ENST00000372352 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000467138 | ENST00000372351 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
| 3UTR-3UTR | ENST00000467138 | ENST00000467138 | EXOSC2 | chr9 | 133579337 | + | EXOSC2 | chr9 | 133579227 | - |
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FusionProtFeatures for EXOSC2_EXOSC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EXOSC2 | EXOSC2 |