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Fusion gene ID: 12238

FusionGeneSummary for EWSR1_NR4A3

Fusion gene summary

Fusion gene information	Fusion gene name: EWSR1_NR4A3
	Fusion gene ID: 12238
		Hgene	Tgene
	Gene symbol	EWSR1	NR4A3
	Gene ID	2130	8013
	Gene name	EWS RNA binding protein 1	nuclear receptor subfamily 4 group A member 3
	Synonyms	EWS\|EWS-FLI1\|bK984G1.4	CHN\|CSMF\|MINOR\|NOR1\|TEC
	Cytomap	22q12.2	9q31.1
	Type of gene	protein-coding	protein-coding
	Description	RNA-binding protein EWSEWS RNA-binding protein variant 6Ewing sarcoma breakpoint region 1Ewings sarcoma EWS-Fli1 (type 1) oncogene	nuclear receptor subfamily 4 group A member 3chondrosarcoma, extraskeletal myxoid, fused to EWSmitogen-induced nuclear orphan receptorneuron-derived orphan receptor 1nuclear hormone receptor NOR-1translocated in extraskeletal chondrosarcoma
	Modification date	20180527	20180527
	UniProtAcc	Q01844	Q92570
	Ensembl transtripts involved in fusion gene	ENST00000332050, ENST00000397938, ENST00000406548, ENST00000331029, ENST00000414183, ENST00000333395, ENST00000332035,	ENST00000338488, ENST00000395097, ENST00000330847,
Fusion gene scores	* DoF score	17 X 31 X 5=2635	6 X 6 X 4=144
	# samples	53	10
	** MAII score	log2(53/2635*10)=-2.31373869707402 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/144*10)=-0.526068811667588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EWSR1 [Title/Abstract] AND NR4A3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NR4A3	GO:0010828	positive regulation of glucose transmembrane transport	24022864
Tgene	NR4A3	GO:0045944	positive regulation of transcription by RNA polymerase II	20558821
Tgene	NR4A3	GO:0048008	platelet-derived growth factor receptor signaling pathway	23554459
Tgene	NR4A3	GO:0048660	regulation of smooth muscle cell proliferation	25852083

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AF524261	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
ChiTaRS3.1			S81242	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000332050	ENST00000338488	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000332050	ENST00000395097	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000332050	ENST00000330847	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000397938	ENST00000338488	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000397938	ENST00000395097	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000397938	ENST00000330847	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000406548	ENST00000338488	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000406548	ENST00000395097	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000406548	ENST00000330847	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
intron-intron	ENST00000331029	ENST00000338488	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
intron-intron	ENST00000331029	ENST00000395097	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
intron-intron	ENST00000331029	ENST00000330847	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000414183	ENST00000338488	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000414183	ENST00000395097	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000414183	ENST00000330847	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
intron-intron	ENST00000333395	ENST00000338488	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
intron-intron	ENST00000333395	ENST00000395097	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
intron-intron	ENST00000333395	ENST00000330847	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000332035	ENST00000338488	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000332035	ENST00000395097	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-intron	ENST00000332035	ENST00000330847	EWSR1	chr22	29688159	+	NR4A3	chr9	102589010	+
5CDS-5UTR	ENST00000332050	ENST00000338488	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000332050	ENST00000395097	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-intron	ENST00000332050	ENST00000330847	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000397938	ENST00000338488	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000397938	ENST00000395097	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-intron	ENST00000397938	ENST00000330847	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000406548	ENST00000338488	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000406548	ENST00000395097	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-intron	ENST00000406548	ENST00000330847	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000331029	ENST00000338488	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000331029	ENST00000395097	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-intron	ENST00000331029	ENST00000330847	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000414183	ENST00000338488	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000414183	ENST00000395097	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-intron	ENST00000414183	ENST00000330847	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000333395	ENST00000338488	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000333395	ENST00000395097	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-intron	ENST00000333395	ENST00000330847	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000332035	ENST00000338488	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-5UTR	ENST00000332035	ENST00000395097	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+
5CDS-intron	ENST00000332035	ENST00000330847	EWSR1	chr22	29683123	+	NR4A3	chr9	102587941	+

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FusionProtFeatures for EWSR1_NR4A3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EWSR1 Q01844	NR4A3 Q92570

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Fusion gene ID: 12238

FusionGeneSummary for EWSR1_NR4A3

FusionProtFeatures for EWSR1_NR4A3