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Fusion gene ID: 12111 |
FusionGeneSummary for ESRRG_MT4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ESRRG_MT4 | Fusion gene ID: 12111 | Hgene | Tgene | Gene symbol | ESRRG | MT4 | Gene ID | 2104 | 84560 |
| Gene name | estrogen related receptor gamma | metallothionein 4 | |
| Synonyms | ERR-gamma|ERR3|ERRg|ERRgamma|NR3B3 | MT-4|MT-IV|MTIV | |
| Cytomap | 1q41 | 16q13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | estrogen-related receptor gammaERR gamma-2estrogen receptor-related protein 3nuclear receptor subfamily 3 group B member 3 | metallothionein-4metallothionein-IV | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P62508 | P47944 | |
| Ensembl transtripts involved in fusion gene | ENST00000361525, ENST00000366940, ENST00000361395, ENST00000366938, ENST00000359162, ENST00000493603, ENST00000463665, ENST00000487276, ENST00000493748, ENST00000471371, ENST00000391890, ENST00000366937, ENST00000408911, ENST00000360012, | ENST00000219162, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 3 X 2 X 3=18 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ESRRG [Title/Abstract] AND MT4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ESRRG | GO:0006355 | regulation of transcription, DNA-templated | 23836911 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF759140 | ESRRG | chr1 | 217007502 | + | MT4 | chr16 | 56601783 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000361525 | ENST00000219162 | ESRRG | chr1 | 217007502 | + | MT4 | chr16 | 56601783 | - |
| intron-intron | ENST00000366940 | ENST00000219162 | ESRRG | chr1 | 217007502 | + | MT4 | chr16 | 56601783 | - |
| intron-intron | ENST00000361395 | ENST00000219162 | ESRRG | chr1 | 217007502 | + | MT4 | chr16 | 56601783 | - |
| intron-intron | ENST00000366938 | ENST00000219162 | ESRRG | chr1 | 217007502 | + | MT4 | chr16 | 56601783 | - |
| intron-intron | ENST00000359162 | ENST00000219162 | ESRRG | chr1 | 217007502 | + | MT4 | chr16 | 56601783 | - |
| intron-intron | ENST00000493603 | ENST00000219162 | ESRRG | chr1 | 217007502 | + | MT4 | chr16 | 56601783 | - |
| intron-intron | ENST00000463665 | ENST00000219162 | ESRRG | chr1 | 217007502 | + | MT4 | chr16 | 56601783 | - |
| intron-intron | ENST00000487276 | ENST00000219162 | ESRRG | chr1 | 217007502 | + | MT4 | chr16 | 56601783 | - |
| intron-intron | ENST00000493748 | ENST00000219162 | ESRRG | chr1 | 217007502 | + | MT4 | chr16 | 56601783 | - |
| intron-intron | ENST00000471371 | ENST00000219162 | ESRRG | chr1 | 217007502 | + | MT4 | chr16 | 56601783 | - |
| intron-intron | ENST00000391890 | ENST00000219162 | ESRRG | chr1 | 217007502 | + | MT4 | chr16 | 56601783 | - |
| intron-intron | ENST00000366937 | ENST00000219162 | ESRRG | chr1 | 217007502 | + | MT4 | chr16 | 56601783 | - |
| intron-intron | ENST00000408911 | ENST00000219162 | ESRRG | chr1 | 217007502 | + | MT4 | chr16 | 56601783 | - |
| intron-intron | ENST00000360012 | ENST00000219162 | ESRRG | chr1 | 217007502 | + | MT4 | chr16 | 56601783 | - |
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FusionProtFeatures for ESRRG_MT4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ESRRG | MT4 |