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Fusion gene ID: 12073 |
FusionGeneSummary for ESCO1_FAM210A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ESCO1_FAM210A | Fusion gene ID: 12073 | Hgene | Tgene | Gene symbol | ESCO1 | FAM210A | Gene ID | 114799 | 125228 |
| Gene name | establishment of sister chromatid cohesion N-acetyltransferase 1 | family with sequence similarity 210 member A | |
| Synonyms | A930014I12Rik|CTF|ECO1|EFO1|ESO1 | C18orf19|HsT2329 | |
| Cytomap | 18q11.2 | 18p11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | N-acetyltransferase ESCO1CTF7 homolog 1ECO1 homolog 1EFO1pESO1 homolog 1N-acetyltransferase ESCO1 variant 2establishment factor-like protein 1establishment of cohesion 1 homolog 1hEFO1 | protein FAM210Auncharacterized protein C18orf19 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q5FWF5 | Q96ND0 | |
| Ensembl transtripts involved in fusion gene | ENST00000269214, ENST00000580101, | ENST00000322247, ENST00000402563, ENST00000588475, | |
| Fusion gene scores | * DoF score | 10 X 5 X 7=350 | 1 X 1 X 1=1 |
| # samples | 13 | 2 | |
| ** MAII score | log2(13/350*10)=-1.42884329880387 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/1*10)=4.32192809488736 | |
| Context | PubMed: ESCO1 [Title/Abstract] AND FAM210A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ESCO1 | GO:0018394 | peptidyl-lysine acetylation | 27112597 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BC022410 | ESCO1 | chr18 | 19180584 | - | FAM210A | chr18 | 13682106 | - | ||
| ChiTaRS3.1 | BG616150 | ESCO1 | chr18 | 19180584 | - | FAM210A | chr18 | 13682106 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000269214 | ENST00000322247 | ESCO1 | chr18 | 19180584 | - | FAM210A | chr18 | 13682106 | - |
| 5UTR-5UTR | ENST00000269214 | ENST00000402563 | ESCO1 | chr18 | 19180584 | - | FAM210A | chr18 | 13682106 | - |
| 5UTR-5UTR | ENST00000269214 | ENST00000588475 | ESCO1 | chr18 | 19180584 | - | FAM210A | chr18 | 13682106 | - |
| 5UTR-5UTR | ENST00000580101 | ENST00000322247 | ESCO1 | chr18 | 19180584 | - | FAM210A | chr18 | 13682106 | - |
| 5UTR-5UTR | ENST00000580101 | ENST00000402563 | ESCO1 | chr18 | 19180584 | - | FAM210A | chr18 | 13682106 | - |
| 5UTR-5UTR | ENST00000580101 | ENST00000588475 | ESCO1 | chr18 | 19180584 | - | FAM210A | chr18 | 13682106 | - |
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FusionProtFeatures for ESCO1_FAM210A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ESCO1 | FAM210A |