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Fusion gene ID: 12034 |
FusionGeneSummary for ERICH1_PCM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ERICH1_PCM1 | Fusion gene ID: 12034 | Hgene | Tgene | Gene symbol | ERICH1 | PCM1 | Gene ID | 157697 | 5108 |
| Gene name | glutamate rich 1 | pericentriolar material 1 | |
| Synonyms | HSPC319 | PTC4|RET/PCM-1 | |
| Cytomap | 8p23.3 | 8p22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glutamate-rich protein 1 | pericentriolar material 1 proteinPCM-1hPCM-1pericentriolar material 1, PCM1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q86X53 | Q15154 | |
| Ensembl transtripts involved in fusion gene | ENST00000522706, ENST00000262109, ENST00000518277, | ENST00000325083, ENST00000519253, ENST00000524226, ENST00000518537, ENST00000518936, ENST00000327578, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 5 X 5 X 3=75 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ERICH1 [Title/Abstract] AND PCM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E2-A14T-01A | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000522706 | ENST00000325083 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| intron-3CDS | ENST00000522706 | ENST00000519253 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| intron-3CDS | ENST00000522706 | ENST00000524226 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| intron-intron | ENST00000522706 | ENST00000518537 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| intron-intron | ENST00000522706 | ENST00000518936 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| intron-intron | ENST00000522706 | ENST00000327578 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| Frame-shift | ENST00000262109 | ENST00000325083 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| Frame-shift | ENST00000262109 | ENST00000519253 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| Frame-shift | ENST00000262109 | ENST00000524226 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| 5CDS-intron | ENST00000262109 | ENST00000518537 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| 5CDS-intron | ENST00000262109 | ENST00000518936 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| 5CDS-intron | ENST00000262109 | ENST00000327578 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| 5UTR-3CDS | ENST00000518277 | ENST00000325083 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| 5UTR-3CDS | ENST00000518277 | ENST00000519253 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| 5UTR-3CDS | ENST00000518277 | ENST00000524226 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| 5UTR-intron | ENST00000518277 | ENST00000518537 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| 5UTR-intron | ENST00000518277 | ENST00000518936 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
| 5UTR-intron | ENST00000518277 | ENST00000327578 | ERICH1 | chr8 | 665861 | - | PCM1 | chr8 | 17882870 | + |
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FusionProtFeatures for ERICH1_PCM1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ERICH1 | PCM1 |