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Fusion gene ID: 12001 |
FusionGeneSummary for ERGIC1_ZZEF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ERGIC1_ZZEF1 | Fusion gene ID: 12001 | Hgene | Tgene | Gene symbol | ERGIC1 | ZZEF1 | Gene ID | 57222 | 23140 |
| Gene name | endoplasmic reticulum-golgi intermediate compartment 1 | zinc finger ZZ-type and EF-hand domain containing 1 | |
| Synonyms | AMCN|ERGIC-32|ERGIC32|NET24 | ZZZ4 | |
| Cytomap | 5q35.1 | 17p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | endoplasmic reticulum-Golgi intermediate compartment protein 1ER-Golgi intermediate compartment 32 kDa proteinendoplasmic reticulum-golgi intermediate compartment (ERGIC) 1endoplasmic reticulum-golgi intermediate compartment 32 kDa protein | zinc finger ZZ-type and EF-hand domain-containing protein 1zinc finger, ZZ-type with EF hand domain 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q969X5 | O43149 | |
| Ensembl transtripts involved in fusion gene | ENST00000393784, ENST00000519860, ENST00000523291, ENST00000326654, | ENST00000381638, ENST00000574474, | |
| Fusion gene scores | * DoF score | 11 X 13 X 6=858 | 9 X 11 X 5=495 |
| # samples | 20 | 14 | |
| ** MAII score | log2(20/858*10)=-2.10097764772482 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/495*10)=-1.82200169802201 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ERGIC1 [Title/Abstract] AND ZZEF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ERGIC1 | GO:0006888 | ER to Golgi vesicle-mediated transport | 15308636 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF509585 | ERGIC1 | chr5 | 172378928 | - | ZZEF1 | chr17 | 3999957 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000393784 | ENST00000381638 | ERGIC1 | chr5 | 172378928 | - | ZZEF1 | chr17 | 3999957 | + |
| 3UTR-5UTR | ENST00000393784 | ENST00000574474 | ERGIC1 | chr5 | 172378928 | - | ZZEF1 | chr17 | 3999957 | + |
| intron-3CDS | ENST00000519860 | ENST00000381638 | ERGIC1 | chr5 | 172378928 | - | ZZEF1 | chr17 | 3999957 | + |
| intron-5UTR | ENST00000519860 | ENST00000574474 | ERGIC1 | chr5 | 172378928 | - | ZZEF1 | chr17 | 3999957 | + |
| intron-3CDS | ENST00000523291 | ENST00000381638 | ERGIC1 | chr5 | 172378928 | - | ZZEF1 | chr17 | 3999957 | + |
| intron-5UTR | ENST00000523291 | ENST00000574474 | ERGIC1 | chr5 | 172378928 | - | ZZEF1 | chr17 | 3999957 | + |
| intron-3CDS | ENST00000326654 | ENST00000381638 | ERGIC1 | chr5 | 172378928 | - | ZZEF1 | chr17 | 3999957 | + |
| intron-5UTR | ENST00000326654 | ENST00000574474 | ERGIC1 | chr5 | 172378928 | - | ZZEF1 | chr17 | 3999957 | + |
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FusionProtFeatures for ERGIC1_ZZEF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ERGIC1 | ZZEF1 |