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Fusion gene ID: 11942 |
FusionGeneSummary for ERBB3_TRIM37 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ERBB3_TRIM37 | Fusion gene ID: 11942 | Hgene | Tgene | Gene symbol | ERBB3 | TRIM37 | Gene ID | 2065 | 4591 |
| Gene name | erb-b2 receptor tyrosine kinase 3 | tripartite motif containing 37 | |
| Synonyms | ErbB-3|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3 | MUL|POB1|TEF3 | |
| Cytomap | 12q13.2 | 17q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | receptor tyrosine-protein kinase erbB-3human epidermal growth factor receptor 3proto-oncogene-like protein c-ErbB-3tyrosine kinase-type cell surface receptor HER3v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 | E3 ubiquitin-protein ligase TRIM37RING-B-box-coiled-coil proteinRING-type E3 ubiquitin transferase TRIM37mulibrey nanism protein | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | P21860 | O94972 | |
| Ensembl transtripts involved in fusion gene | ENST00000267101, ENST00000450146, ENST00000415288, ENST00000553131, ENST00000411731, ENST00000549832, | ENST00000393066, ENST00000262294, ENST00000376149, ENST00000393065, ENST00000584889, | |
| Fusion gene scores | * DoF score | 16 X 15 X 9=2160 | 7 X 6 X 7=294 |
| # samples | 16 | 7 | |
| ** MAII score | log2(16/2160*10)=-3.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ERBB3 [Title/Abstract] AND TRIM37 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ERBB3 | GO:0007162 | negative regulation of cell adhesion | 7556068 |
| Hgene | ERBB3 | GO:0007165 | signal transduction | 10572067 |
| Hgene | ERBB3 | GO:0009968 | negative regulation of signal transduction | 11389077 |
| Hgene | ERBB3 | GO:0014065 | phosphatidylinositol 3-kinase signaling | 7556068 |
| Hgene | ERBB3 | GO:0042127 | regulation of cell proliferation | 11389077 |
| Hgene | ERBB3 | GO:0051048 | negative regulation of secretion | 10559227 |
| Tgene | TRIM37 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 25470042 |
| Tgene | TRIM37 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 11279055 |
| Tgene | TRIM37 | GO:0035518 | histone H2A monoubiquitination | 25470042 |
| Tgene | TRIM37 | GO:0036353 | histone H2A-K119 monoubiquitination | 25470042 |
| Tgene | TRIM37 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 23077300 |
| Tgene | TRIM37 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 23077300 |
| Tgene | TRIM37 | GO:0051865 | protein autoubiquitination | 15885686 |
| Tgene | TRIM37 | GO:0070842 | aggresome assembly | 15885686 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DN914711 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000267101 | ENST00000393066 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000267101 | ENST00000262294 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000267101 | ENST00000376149 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000267101 | ENST00000393065 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000267101 | ENST00000584889 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000450146 | ENST00000393066 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000450146 | ENST00000262294 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000450146 | ENST00000376149 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000450146 | ENST00000393065 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000450146 | ENST00000584889 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000415288 | ENST00000393066 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000415288 | ENST00000262294 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000415288 | ENST00000376149 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000415288 | ENST00000393065 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000415288 | ENST00000584889 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000553131 | ENST00000393066 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000553131 | ENST00000262294 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000553131 | ENST00000376149 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000553131 | ENST00000393065 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000553131 | ENST00000584889 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| intron-intron | ENST00000411731 | ENST00000393066 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| intron-3UTR | ENST00000411731 | ENST00000262294 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| intron-3UTR | ENST00000411731 | ENST00000376149 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| intron-3UTR | ENST00000411731 | ENST00000393065 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| intron-intron | ENST00000411731 | ENST00000584889 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000549832 | ENST00000393066 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000549832 | ENST00000262294 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000549832 | ENST00000376149 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000549832 | ENST00000393065 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000549832 | ENST00000584889 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
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FusionProtFeatures for ERBB3_TRIM37 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ERBB3 | TRIM37 |