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Fusion gene ID: 11897

FusionGeneSummary for ERBB2IP_PPWD1

Fusion gene summary

Fusion gene information	Fusion gene name: ERBB2IP_PPWD1
	Fusion gene ID: 11897
		Hgene	Tgene
	Gene symbol	ERBB2IP	PPWD1
	Gene ID	55914	23398
	Gene name	erbb2 interacting protein	peptidylprolyl isomerase domain and WD repeat containing 1
	Synonyms	ERBB2IP\|HEL-S-78\|LAP2	-
	Cytomap	5q12.3	5q12.3
	Type of gene	protein-coding	protein-coding
	Description	erbindensin-180-like proteinepididymis secretory protein Li 78protein LAP2	peptidylprolyl isomerase domain and WD repeat-containing protein 1spliceosome-associated cyclophilin
	Modification date	20180523	20180523
	UniProtAcc		Q96BP3
	Ensembl transtripts involved in fusion gene	ENST00000284037, ENST00000380943, ENST00000416865, ENST00000380935, ENST00000380939, ENST00000380936, ENST00000380938, ENST00000511297, ENST00000506030, ENST00000508515, ENST00000503913,	ENST00000261308, ENST00000535264, ENST00000538977,
Fusion gene scores	* DoF score	7 X 4 X 4=112	3 X 2 X 3=18
	# samples	7	3
	** MAII score	log2(7/112*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ERBB2IP [Title/Abstract] AND PPWD1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PPWD1	GO:0000413	protein peptidyl-prolyl isomerization	20676357

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BRCA	TCGA-BH-A1FD-01A	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000284037	ENST00000261308	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000284037	ENST00000535264	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000284037	ENST00000538977	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000380943	ENST00000261308	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000380943	ENST00000535264	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000380943	ENST00000538977	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000416865	ENST00000261308	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000416865	ENST00000535264	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000416865	ENST00000538977	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000380935	ENST00000261308	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000380935	ENST00000535264	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000380935	ENST00000538977	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000380939	ENST00000261308	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000380939	ENST00000535264	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000380939	ENST00000538977	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000380936	ENST00000261308	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000380936	ENST00000535264	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000380936	ENST00000538977	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000380938	ENST00000261308	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000380938	ENST00000535264	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000380938	ENST00000538977	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000511297	ENST00000261308	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000511297	ENST00000535264	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000511297	ENST00000538977	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000506030	ENST00000261308	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000506030	ENST00000535264	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
5UTR-3CDS	ENST00000506030	ENST00000538977	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
intron-3CDS	ENST00000508515	ENST00000261308	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
intron-3CDS	ENST00000508515	ENST00000535264	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
intron-3CDS	ENST00000508515	ENST00000538977	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
intron-3CDS	ENST00000503913	ENST00000261308	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
intron-3CDS	ENST00000503913	ENST00000535264	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+
intron-3CDS	ENST00000503913	ENST00000538977	ERBB2IP	chr5	65222634	+	PPWD1	chr5	64872706	+

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FusionProtFeatures for ERBB2IP_PPWD1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ERBB2IP	PPWD1 Q96BP3

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Fusion gene ID: 11897

FusionGeneSummary for ERBB2IP_PPWD1

FusionProtFeatures for ERBB2IP_PPWD1