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Fusion gene ID: 11881 |
FusionGeneSummary for EPS8_PLEKHA5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EPS8_PLEKHA5 | Fusion gene ID: 11881 | Hgene | Tgene | Gene symbol | EPS8 | PLEKHA5 | Gene ID | 2059 | 54477 |
| Gene name | epidermal growth factor receptor pathway substrate 8 | pleckstrin homology domain containing A5 | |
| Synonyms | DFNB102 | PEPP-2|PEPP2 | |
| Cytomap | 12p12.3 | 12p12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | epidermal growth factor receptor kinase substrate 8 | pleckstrin homology domain-containing family A member 5PH domain-containing family A member 5phosphoinositol 3-phosphate-binding protein-2pleckstrin homology domain containing, family A member 5 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q12929 | Q9HAU0 | |
| Ensembl transtripts involved in fusion gene | ENST00000543523, ENST00000281172, ENST00000543612, ENST00000540613, ENST00000542903, | ENST00000309364, ENST00000359180, ENST00000317589, ENST00000355397, ENST00000429027, ENST00000539256, ENST00000299275, ENST00000538714, ENST00000543806, ENST00000424268, ENST00000540972, ENST00000510738, | |
| Fusion gene scores | * DoF score | 10 X 4 X 6=240 | 21 X 8 X 13=2184 |
| # samples | 10 | 22 | |
| ** MAII score | log2(10/240*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(22/2184*10)=-3.31139742739519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EPS8 [Title/Abstract] AND PLEKHA5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | OV | TCGA-61-2102-01A | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-intron | ENST00000543523 | ENST00000309364 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000543523 | ENST00000359180 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000543523 | ENST00000317589 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000543523 | ENST00000355397 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000543523 | ENST00000429027 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000543523 | ENST00000539256 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000543523 | ENST00000299275 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000543523 | ENST00000538714 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000543523 | ENST00000543806 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000543523 | ENST00000424268 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000543523 | ENST00000540972 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000543523 | ENST00000510738 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000281172 | ENST00000309364 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000281172 | ENST00000359180 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000281172 | ENST00000317589 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000281172 | ENST00000355397 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000281172 | ENST00000429027 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000281172 | ENST00000539256 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000281172 | ENST00000299275 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000281172 | ENST00000538714 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000281172 | ENST00000543806 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000281172 | ENST00000424268 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000281172 | ENST00000540972 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| 5UTR-intron | ENST00000281172 | ENST00000510738 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000543612 | ENST00000309364 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000543612 | ENST00000359180 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000543612 | ENST00000317589 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000543612 | ENST00000355397 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000543612 | ENST00000429027 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000543612 | ENST00000539256 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000543612 | ENST00000299275 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000543612 | ENST00000538714 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000543612 | ENST00000543806 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000543612 | ENST00000424268 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000543612 | ENST00000540972 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000543612 | ENST00000510738 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000540613 | ENST00000309364 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000540613 | ENST00000359180 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000540613 | ENST00000317589 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000540613 | ENST00000355397 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000540613 | ENST00000429027 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000540613 | ENST00000539256 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000540613 | ENST00000299275 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000540613 | ENST00000538714 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000540613 | ENST00000543806 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000540613 | ENST00000424268 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000540613 | ENST00000540972 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000540613 | ENST00000510738 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000542903 | ENST00000309364 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000542903 | ENST00000359180 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000542903 | ENST00000317589 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000542903 | ENST00000355397 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000542903 | ENST00000429027 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000542903 | ENST00000539256 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000542903 | ENST00000299275 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000542903 | ENST00000538714 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000542903 | ENST00000543806 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000542903 | ENST00000424268 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000542903 | ENST00000540972 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
| intron-intron | ENST00000542903 | ENST00000510738 | EPS8 | chr12 | 15942095 | - | PLEKHA5 | chr12 | 19489449 | + |
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FusionProtFeatures for EPS8_PLEKHA5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EPS8 | PLEKHA5 |