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Fusion gene ID: 1188 |
FusionGeneSummary for AHCYL1_MAN1A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AHCYL1_MAN1A2 | Fusion gene ID: 1188 | Hgene | Tgene | Gene symbol | AHCYL1 | MAN1A2 | Gene ID | 10768 | 10905 |
| Gene name | adenosylhomocysteinase like 1 | mannosidase alpha class 1A member 2 | |
| Synonyms | DCAL|IRBIT|PPP1R78|PRO0233|XPVKONA | MAN1B | |
| Cytomap | 1p13.3 | 1p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | S-adenosylhomocysteine hydrolase-like protein 1DC-expressed AHCY-like moleculeIP(3)Rs binding protein released with IP(3)S-adenosyl homocysteine hydrolase homologS-adenosyl-L-homocysteine hydrolase 2adenosylhomocysteinase 2adoHcyase 2dendritic cell | mannosyl-oligosaccharide 1,2-alpha-mannosidase IBalpha-1,2-mannosidase IBalpha1,2-mannosidaseprocessing alpha-1,2-mannosidase IB | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O43865 | O60476 | |
| Ensembl transtripts involved in fusion gene | ENST00000369799, ENST00000475081, ENST00000359172, ENST00000393614, | ENST00000356554, ENST00000482811, | |
| Fusion gene scores | * DoF score | 10 X 9 X 4=360 | 10 X 8 X 5=400 |
| # samples | 12 | 16 | |
| ** MAII score | log2(12/360*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/400*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AHCYL1 [Title/Abstract] AND MAN1A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AHCYL1 | GO:0006378 | mRNA polyadenylation | 19224921 |
| Hgene | AHCYL1 | GO:0031440 | regulation of mRNA 3'-end processing | 19224921 |
| Hgene | AHCYL1 | GO:0038166 | angiotensin-activated signaling pathway | 20584908 |
| Hgene | AHCYL1 | GO:0051592 | response to calcium ion | 18829453 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-C8-A26Z-01A | AHCYL1 | chr1 | 110527794 | + | MAN1A2 | chr1 | 117944808 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000369799 | ENST00000356554 | AHCYL1 | chr1 | 110527794 | + | MAN1A2 | chr1 | 117944808 | + |
| 5CDS-intron | ENST00000369799 | ENST00000482811 | AHCYL1 | chr1 | 110527794 | + | MAN1A2 | chr1 | 117944808 | + |
| 3UTR-3CDS | ENST00000475081 | ENST00000356554 | AHCYL1 | chr1 | 110527794 | + | MAN1A2 | chr1 | 117944808 | + |
| 3UTR-intron | ENST00000475081 | ENST00000482811 | AHCYL1 | chr1 | 110527794 | + | MAN1A2 | chr1 | 117944808 | + |
| intron-3CDS | ENST00000359172 | ENST00000356554 | AHCYL1 | chr1 | 110527794 | + | MAN1A2 | chr1 | 117944808 | + |
| intron-intron | ENST00000359172 | ENST00000482811 | AHCYL1 | chr1 | 110527794 | + | MAN1A2 | chr1 | 117944808 | + |
| intron-3CDS | ENST00000393614 | ENST00000356554 | AHCYL1 | chr1 | 110527794 | + | MAN1A2 | chr1 | 117944808 | + |
| intron-intron | ENST00000393614 | ENST00000482811 | AHCYL1 | chr1 | 110527794 | + | MAN1A2 | chr1 | 117944808 | + |
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FusionProtFeatures for AHCYL1_MAN1A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AHCYL1 | MAN1A2 |