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Fusion gene ID: 11865 |
FusionGeneSummary for EPS15_CCT4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EPS15_CCT4 | Fusion gene ID: 11865 | Hgene | Tgene | Gene symbol | EPS15 | CCT4 | Gene ID | 2060 | 10575 |
| Gene name | epidermal growth factor receptor pathway substrate 15 | chaperonin containing TCP1 subunit 4 | |
| Synonyms | AF-1P|AF1P|MLLT5 | CCT-DELTA|Cctd|SRB | |
| Cytomap | 1p32.3 | 2p15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | epidermal growth factor receptor substrate 15ALL1 fused gene from chromosome 1protein AF-1p | T-complex protein 1 subunit deltaTCP-1-deltachaperonin containing TCP1, subunit 4 (delta)chaperonin containing t-complex polypeptide 1, delta subunitstimulator of TAR RNA-binding | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P42566 | P50991 | |
| Ensembl transtripts involved in fusion gene | ENST00000371730, ENST00000371733, ENST00000396122, ENST00000493793, | ENST00000394440, ENST00000461540, ENST00000544079, ENST00000544185, ENST00000538252, | |
| Fusion gene scores | * DoF score | 10 X 7 X 8=560 | 5 X 6 X 4=120 |
| # samples | 10 | 6 | |
| ** MAII score | log2(10/560*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EPS15 [Title/Abstract] AND CCT4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EPS15 | GO:0048268 | clathrin coat assembly | 12807910 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCS | TCGA-N5-A4RJ-01A | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000371730 | ENST00000394440 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| 5CDS-5UTR | ENST00000371730 | ENST00000461540 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| 5CDS-5UTR | ENST00000371730 | ENST00000544079 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| 5CDS-5UTR | ENST00000371730 | ENST00000544185 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| 5CDS-5UTR | ENST00000371730 | ENST00000538252 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| Frame-shift | ENST00000371733 | ENST00000394440 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| 5CDS-5UTR | ENST00000371733 | ENST00000461540 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| 5CDS-5UTR | ENST00000371733 | ENST00000544079 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| 5CDS-5UTR | ENST00000371733 | ENST00000544185 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| 5CDS-5UTR | ENST00000371733 | ENST00000538252 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| Frame-shift | ENST00000396122 | ENST00000394440 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| 5CDS-5UTR | ENST00000396122 | ENST00000461540 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| 5CDS-5UTR | ENST00000396122 | ENST00000544079 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| 5CDS-5UTR | ENST00000396122 | ENST00000544185 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| 5CDS-5UTR | ENST00000396122 | ENST00000538252 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| intron-3CDS | ENST00000493793 | ENST00000394440 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| intron-5UTR | ENST00000493793 | ENST00000461540 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| intron-5UTR | ENST00000493793 | ENST00000544079 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| intron-5UTR | ENST00000493793 | ENST00000544185 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
| intron-5UTR | ENST00000493793 | ENST00000538252 | EPS15 | chr1 | 51868107 | - | CCT4 | chr2 | 62096688 | - |
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FusionProtFeatures for EPS15_CCT4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EPS15 | CCT4 |