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Fusion gene ID: 11848 |
FusionGeneSummary for EPS15L1_BRD4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EPS15L1_BRD4 | Fusion gene ID: 11848 | Hgene | Tgene | Gene symbol | EPS15L1 | BRD4 | Gene ID | 58513 | 23476 |
| Gene name | epidermal growth factor receptor pathway substrate 15 like 1 | bromodomain containing 4 | |
| Synonyms | EPS15R | CAP|HUNK1|HUNKI|MCAP | |
| Cytomap | 19p13.11 | 19p13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | epidermal growth factor receptor substrate 15-like 1epidermal growth factor receptor substrate EPS15Reps15-related protein | bromodomain-containing protein 4chromosome-associated protein | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q9UBC2 | O60885 | |
| Ensembl transtripts involved in fusion gene | ENST00000455140, ENST00000248070, ENST00000535753, ENST00000594975, ENST00000602009, ENST00000597937, | ENST00000263377, ENST00000371835, ENST00000360016, ENST00000602230, | |
| Fusion gene scores | * DoF score | 15 X 11 X 10=1650 | 8 X 10 X 6=480 |
| # samples | 18 | 12 | |
| ** MAII score | log2(18/1650*10)=-3.1963972128035 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/480*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EPS15L1 [Title/Abstract] AND BRD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | BRD4 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter | 19103749|23086925 |
| Tgene | BRD4 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 19103749 |
| Tgene | BRD4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23086925|23317504 |
| Tgene | BRD4 | GO:0050727 | regulation of inflammatory response | 19103749 |
| Tgene | BRD4 | GO:1901407 | regulation of phosphorylation of RNA polymerase II C-terminal domain | 23086925 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AC-A2FM-01A | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000455140 | ENST00000263377 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-5UTR | ENST00000455140 | ENST00000371835 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-5UTR | ENST00000455140 | ENST00000360016 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-intron | ENST00000455140 | ENST00000602230 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-5UTR | ENST00000248070 | ENST00000263377 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-5UTR | ENST00000248070 | ENST00000371835 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-5UTR | ENST00000248070 | ENST00000360016 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-intron | ENST00000248070 | ENST00000602230 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-5UTR | ENST00000535753 | ENST00000263377 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-5UTR | ENST00000535753 | ENST00000371835 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-5UTR | ENST00000535753 | ENST00000360016 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-intron | ENST00000535753 | ENST00000602230 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-5UTR | ENST00000594975 | ENST00000263377 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-5UTR | ENST00000594975 | ENST00000371835 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-5UTR | ENST00000594975 | ENST00000360016 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-intron | ENST00000594975 | ENST00000602230 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-5UTR | ENST00000602009 | ENST00000263377 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-5UTR | ENST00000602009 | ENST00000371835 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-5UTR | ENST00000602009 | ENST00000360016 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-intron | ENST00000602009 | ENST00000602230 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-5UTR | ENST00000597937 | ENST00000263377 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-5UTR | ENST00000597937 | ENST00000371835 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-5UTR | ENST00000597937 | ENST00000360016 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
| 5CDS-intron | ENST00000597937 | ENST00000602230 | EPS15L1 | chr19 | 16545176 | - | BRD4 | chr19 | 15383944 | - |
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FusionProtFeatures for EPS15L1_BRD4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EPS15L1 | BRD4 |