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Fusion gene ID: 11808

FusionGeneSummary for EPHA5_RUFY3

Fusion gene summary

Fusion gene information	Fusion gene name: EPHA5_RUFY3
	Fusion gene ID: 11808
		Hgene	Tgene
	Gene symbol	EPHA5	RUFY3
	Gene ID	2044	79443
	Gene name	EPH receptor A5	FYVE and coiled-coil domain containing 1
	Synonyms	CEK7\|EHK-1\|EHK1\|EK7\|HEK7\|TYRO4	CATC2\|CTRCT18\|RUFY3\|ZFYVE7
	Cytomap	4q13.1-q13.2	3p21.31
	Type of gene	protein-coding	protein-coding
	Description	ephrin type-A receptor 5EPH homology kinase 1EPH-like kinase 7brain-specific kinasereceptor protein-tyrosine kinase HEK7tyrosine-protein kinase receptor EHK-1	FYVE and coiled-coil domain-containing protein 1RUN and FYVE domain containing 3zinc finger FYVE domain-containing protein 7
	Modification date	20180523	20180523
	UniProtAcc	P54756	Q7L099
	Ensembl transtripts involved in fusion gene	ENST00000273854, ENST00000432638, ENST00000354839, ENST00000511294,	ENST00000417478, ENST00000381006, ENST00000226328, ENST00000536664, ENST00000502653, ENST00000512331,
Fusion gene scores	* DoF score	3 X 3 X 2=18	3 X 3 X 3=27
	# samples	3	4
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: EPHA5 [Title/Abstract] AND RUFY3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LUAD	TCGA-91-6848-01A	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000273854	ENST00000417478	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
In-frame	ENST00000273854	ENST00000381006	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
In-frame	ENST00000273854	ENST00000226328	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
In-frame	ENST00000273854	ENST00000536664	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
In-frame	ENST00000273854	ENST00000502653	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
5CDS-intron	ENST00000273854	ENST00000512331	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
intron-3CDS	ENST00000432638	ENST00000417478	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
intron-3CDS	ENST00000432638	ENST00000381006	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
intron-3CDS	ENST00000432638	ENST00000226328	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
intron-3CDS	ENST00000432638	ENST00000536664	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
intron-3CDS	ENST00000432638	ENST00000502653	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
intron-intron	ENST00000432638	ENST00000512331	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
In-frame	ENST00000354839	ENST00000417478	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
In-frame	ENST00000354839	ENST00000381006	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
In-frame	ENST00000354839	ENST00000226328	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
In-frame	ENST00000354839	ENST00000536664	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
In-frame	ENST00000354839	ENST00000502653	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
5CDS-intron	ENST00000354839	ENST00000512331	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
In-frame	ENST00000511294	ENST00000417478	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
In-frame	ENST00000511294	ENST00000381006	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
In-frame	ENST00000511294	ENST00000226328	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
In-frame	ENST00000511294	ENST00000536664	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
In-frame	ENST00000511294	ENST00000502653	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+
5CDS-intron	ENST00000511294	ENST00000512331	EPHA5	chr4	66356095	-	RUFY3	chr4	71628236	+

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FusionProtFeatures for EPHA5_RUFY3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EPHA5 P54756	RUFY3 Q7L099

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Fusion gene ID: 11808

FusionGeneSummary for EPHA5_RUFY3

FusionProtFeatures for EPHA5_RUFY3