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Fusion gene ID: 1171 |
FusionGeneSummary for AGTPBP1_DAPK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AGTPBP1_DAPK1 | Fusion gene ID: 1171 | Hgene | Tgene | Gene symbol | AGTPBP1 | DAPK1 | Gene ID | 23287 | 1612 |
| Gene name | ATP/GTP binding protein 1 | death associated protein kinase 1 | |
| Synonyms | CCP1|NNA1 | DAPK|ROCO3 | |
| Cytomap | 9q21.33 | 9q21.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytosolic carboxypeptidase 1carboxypeptidase-tubulinnervous system nuclear protein induced by axotomy protein 1 homologsoluble carboxypeptidasetubulinyl-Tyr carboxypeptidasetyrosine carboxypeptidase | death-associated protein kinase 1DAP kinase 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9UPW5 | P53355 | |
| Ensembl transtripts involved in fusion gene | ENST00000337006, ENST00000376083, ENST00000357081, ENST00000376109, ENST00000432218, ENST00000376081, ENST00000491784, ENST00000376080, | ENST00000358077, ENST00000472284, ENST00000469640, ENST00000408954, ENST00000491893, ENST00000466188, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 4 X 5=100 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AGTPBP1 [Title/Abstract] AND DAPK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DAPK1 | GO:0006468 | protein phosphorylation | 10629061 |
| Tgene | DAPK1 | GO:0017148 | negative regulation of translation | 18995835 |
| Tgene | DAPK1 | GO:0035556 | intracellular signal transduction | 10629061 |
| Tgene | DAPK1 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 16132846 |
| Tgene | DAPK1 | GO:0046777 | protein autophosphorylation | 10629061|12730201 |
| Tgene | DAPK1 | GO:0071346 | cellular response to interferon-gamma | 18995835 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-K1-A6RU-01A | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000337006 | ENST00000358077 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000337006 | ENST00000472284 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000337006 | ENST00000469640 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000337006 | ENST00000408954 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000337006 | ENST00000491893 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-intron | ENST00000337006 | ENST00000466188 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000376083 | ENST00000358077 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000376083 | ENST00000472284 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000376083 | ENST00000469640 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000376083 | ENST00000408954 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000376083 | ENST00000491893 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-intron | ENST00000376083 | ENST00000466188 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000357081 | ENST00000358077 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000357081 | ENST00000472284 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000357081 | ENST00000469640 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000357081 | ENST00000408954 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000357081 | ENST00000491893 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-intron | ENST00000357081 | ENST00000466188 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| Frame-shift | ENST00000376109 | ENST00000358077 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| Frame-shift | ENST00000376109 | ENST00000472284 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| Frame-shift | ENST00000376109 | ENST00000469640 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| Frame-shift | ENST00000376109 | ENST00000408954 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| Frame-shift | ENST00000376109 | ENST00000491893 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5CDS-intron | ENST00000376109 | ENST00000466188 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-3CDS | ENST00000432218 | ENST00000358077 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-3CDS | ENST00000432218 | ENST00000472284 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-3CDS | ENST00000432218 | ENST00000469640 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-3CDS | ENST00000432218 | ENST00000408954 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-3CDS | ENST00000432218 | ENST00000491893 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-intron | ENST00000432218 | ENST00000466188 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000376081 | ENST00000358077 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000376081 | ENST00000472284 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000376081 | ENST00000469640 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000376081 | ENST00000408954 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-3CDS | ENST00000376081 | ENST00000491893 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| 5UTR-intron | ENST00000376081 | ENST00000466188 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-3CDS | ENST00000491784 | ENST00000358077 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-3CDS | ENST00000491784 | ENST00000472284 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-3CDS | ENST00000491784 | ENST00000469640 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-3CDS | ENST00000491784 | ENST00000408954 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-3CDS | ENST00000491784 | ENST00000491893 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-intron | ENST00000491784 | ENST00000466188 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-3CDS | ENST00000376080 | ENST00000358077 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-3CDS | ENST00000376080 | ENST00000472284 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-3CDS | ENST00000376080 | ENST00000469640 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-3CDS | ENST00000376080 | ENST00000408954 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-3CDS | ENST00000376080 | ENST00000491893 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
| intron-intron | ENST00000376080 | ENST00000466188 | AGTPBP1 | chr9 | 88356690 | - | DAPK1 | chr9 | 90252858 | + |
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FusionProtFeatures for AGTPBP1_DAPK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AGTPBP1 | DAPK1 |