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Fusion gene ID: 11680 |
FusionGeneSummary for EP300_BCOR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EP300_BCOR | Fusion gene ID: 11680 | Hgene | Tgene | Gene symbol | EP300 | BCOR | Gene ID | 2033 | 54880 |
| Gene name | E1A binding protein p300 | BCL6 corepressor | |
| Synonyms | KAT3B|RSTS2|p300 | ANOP2|MAA2|MCOPS2 | |
| Cytomap | 22q13.2 | Xp11.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone acetyltransferase p300E1A-associated protein p300E1A-binding protein, 300kDhistone butyryltransferase p300histone crotonyltransferase p300p300 HATprotein propionyltransferase p300 | BCL-6 corepressorBCL-6 interacting corepressor | |
| Modification date | 20180527 | 20180527 | |
| UniProtAcc | Q09472 | Q6W2J9 | |
| Ensembl transtripts involved in fusion gene | ENST00000263253, | ENST00000378455, ENST00000342274, ENST00000378463, ENST00000397354, ENST00000378444, | |
| Fusion gene scores | * DoF score | 16 X 11 X 11=1936 | 1 X 1 X 1=1 |
| # samples | 17 | 2 | |
| ** MAII score | log2(17/1936*10)=-3.50947230113689 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/1*10)=4.32192809488736 | |
| Context | PubMed: EP300 [Title/Abstract] AND BCOR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EP300 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10733570 |
| Hgene | EP300 | GO:0001666 | response to hypoxia | 9887100|15261140 |
| Hgene | EP300 | GO:0006355 | regulation of transcription, DNA-templated | 15261140 |
| Hgene | EP300 | GO:0006473 | protein acetylation | 21030595|24939902 |
| Hgene | EP300 | GO:0006475 | internal protein amino acid acetylation | 18722353 |
| Hgene | EP300 | GO:0010742 | macrophage derived foam cell differentiation | 26504087 |
| Hgene | EP300 | GO:0016573 | histone acetylation | 25818647 |
| Hgene | EP300 | GO:0018076 | N-terminal peptidyl-lysine acetylation | 12435739 |
| Hgene | EP300 | GO:0018393 | internal peptidyl-lysine acetylation | 17403783 |
| Hgene | EP300 | GO:0018394 | peptidyl-lysine acetylation | 23962722 |
| Hgene | EP300 | GO:0032460 | negative regulation of protein oligomerization | 23962722 |
| Hgene | EP300 | GO:0034644 | cellular response to UV | 24939902 |
| Hgene | EP300 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 17403783 |
| Hgene | EP300 | GO:0043627 | response to estrogen | 11581164 |
| Hgene | EP300 | GO:0043923 | positive regulation by host of viral transcription | 16687403 |
| Hgene | EP300 | GO:0043969 | histone H2B acetylation | 23415232 |
| Hgene | EP300 | GO:0045815 | positive regulation of gene expression, epigenetic | 25818647 |
| Hgene | EP300 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12586840|18722353 |
| Hgene | EP300 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 10518217|25818647 |
| Hgene | EP300 | GO:0060765 | regulation of androgen receptor signaling pathway | 18487222 |
| Hgene | EP300 | GO:0061921 | peptidyl-lysine propionylation | 17267393 |
| Hgene | EP300 | GO:0090043 | regulation of tubulin deacetylation | 18722353 |
| Hgene | EP300 | GO:0140066 | peptidyl-lysine crotonylation | 25818647 |
| Hgene | EP300 | GO:0140067 | peptidyl-lysine butyrylation | 17267393 |
| Tgene | BCOR | GO:0035518 | histone H2A monoubiquitination | 16943429 |
| Tgene | BCOR | GO:0045892 | negative regulation of transcription, DNA-templated | 10898795 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-DU-6404-01A | EP300 | chr22 | 41572532 | + | BCOR | chrX | 39930412 | - |
| TCGA | RV | LGG | TCGA-DU-6404-02B | EP300 | chr22 | 41572532 | + | BCOR | chrX | 39930412 | - |
| TCGA | LD | LGG | TCGA-DU-6404-01A | EP300 | chr22 | 41573820 | + | BCOR | chrX | 39930412 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000263253 | ENST00000378455 | EP300 | chr22 | 41572532 | + | BCOR | chrX | 39930412 | - |
| In-frame | ENST00000263253 | ENST00000342274 | EP300 | chr22 | 41572532 | + | BCOR | chrX | 39930412 | - |
| 5CDS-intron | ENST00000263253 | ENST00000378463 | EP300 | chr22 | 41572532 | + | BCOR | chrX | 39930412 | - |
| 5CDS-intron | ENST00000263253 | ENST00000397354 | EP300 | chr22 | 41572532 | + | BCOR | chrX | 39930412 | - |
| 5CDS-intron | ENST00000263253 | ENST00000378444 | EP300 | chr22 | 41572532 | + | BCOR | chrX | 39930412 | - |
| Frame-shift | ENST00000263253 | ENST00000378455 | EP300 | chr22 | 41573820 | + | BCOR | chrX | 39930412 | - |
| Frame-shift | ENST00000263253 | ENST00000342274 | EP300 | chr22 | 41573820 | + | BCOR | chrX | 39930412 | - |
| 5CDS-intron | ENST00000263253 | ENST00000378463 | EP300 | chr22 | 41573820 | + | BCOR | chrX | 39930412 | - |
| 5CDS-intron | ENST00000263253 | ENST00000397354 | EP300 | chr22 | 41573820 | + | BCOR | chrX | 39930412 | - |
| 5CDS-intron | ENST00000263253 | ENST00000378444 | EP300 | chr22 | 41573820 | + | BCOR | chrX | 39930412 | - |
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FusionProtFeatures for EP300_BCOR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EP300 | BCOR |