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Fusion gene ID: 11545 |
FusionGeneSummary for EML1_MEG8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EML1_MEG8 | Fusion gene ID: 11545 | Hgene | Tgene | Gene symbol | EML1 | MEG8 | Gene ID | 2009 | 79104 |
| Gene name | echinoderm microtubule associated protein like 1 | maternally expressed 8, small nucleolar RNA host gene | |
| Synonyms | BH|ELP79|EMAP|EMAPL|HuEMAP | Bsr|Irm|LINC00024|NCRNA00024|Rian|SNHG23|SNHG24|lnc-MGC | |
| Cytomap | 14q32.2 | 14q32.2-q32.31 | |
| Type of gene | protein-coding | ncRNA | |
| Description | echinoderm microtubule-associated protein-like 1EMAP-1huEMAP-1 | RNA Imprinted and Accumulated in Nucleusimprinted RNA near Meg3/Gtl2lncRNA microRNA megacluster hostlong intergenic non-protein coding RNA 24maternally expressed (in Callipyge) 8small nucleolar RNA host gene 23 (non-protein coding)small nucleolar RN | |
| Modification date | 20180523 | 20180401 | |
| UniProtAcc | O00423 | ||
| Ensembl transtripts involved in fusion gene | ENST00000327921, ENST00000262233, ENST00000334192, ENST00000556758, | ENST00000458974, | |
| Fusion gene scores | * DoF score | 9 X 4 X 7=252 | 1 X 1 X 1=1 |
| # samples | 9 | 1 | |
| ** MAII score | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: EML1 [Title/Abstract] AND MEG8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PCPG | TCGA-QR-A70J-01A | EML1 | chr14 | 100363631 | + | MEG8 | chr14 | 101311795 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000327921 | ENST00000458974 | EML1 | chr14 | 100363631 | + | MEG8 | chr14 | 101311795 | + |
| 5CDS-intron | ENST00000262233 | ENST00000458974 | EML1 | chr14 | 100363631 | + | MEG8 | chr14 | 101311795 | + |
| 5CDS-intron | ENST00000334192 | ENST00000458974 | EML1 | chr14 | 100363631 | + | MEG8 | chr14 | 101311795 | + |
| intron-intron | ENST00000556758 | ENST00000458974 | EML1 | chr14 | 100363631 | + | MEG8 | chr14 | 101311795 | + |
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FusionProtFeatures for EML1_MEG8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EML1 | MEG8 |