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Fusion gene ID: 11543

FusionGeneSummary for EML1_GPI

Fusion gene summary

Fusion gene information	Fusion gene name: EML1_GPI
	Fusion gene ID: 11543
		Hgene	Tgene
	Gene symbol	EML1	GPI
	Gene ID	2009	10007
	Gene name	echinoderm microtubule associated protein like 1	glucosamine-6-phosphate deaminase 1
	Synonyms	BH\|ELP79\|EMAP\|EMAPL\|HuEMAP	GNP1\|GNPDA\|GNPI\|GPI\|HLN
	Cytomap	14q32.2	5q31.3
	Type of gene	protein-coding	protein-coding
	Description	echinoderm microtubule-associated protein-like 1EMAP-1huEMAP-1	glucosamine-6-phosphate isomerase 1GNPDA 1glcN6P deaminase 1oscillin
	Modification date	20180523	20180523
	UniProtAcc	O00423	P06744
	Ensembl transtripts involved in fusion gene	ENST00000327921, ENST00000262233, ENST00000334192, ENST00000556758,	ENST00000415930, ENST00000356487, ENST00000586425,
Fusion gene scores	* DoF score	9 X 4 X 7=252	9 X 6 X 7=378
	# samples	9	10
	** MAII score	log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EML1 [Title/Abstract] AND GPI [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SARC	TCGA-RN-AAAQ-01A	EML1	chr14	100259880	+	GPI	chr19	34884153	+
TCGA	LD	SARC	TCGA-RN-AAAQ-01A	EML1	chr14	100259880	+	GPI	chr19	34884633	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000327921	ENST00000415930	EML1	chr14	100259880	+	GPI	chr19	34884153	+
intron-3CDS	ENST00000327921	ENST00000356487	EML1	chr14	100259880	+	GPI	chr19	34884153	+
intron-3CDS	ENST00000327921	ENST00000586425	EML1	chr14	100259880	+	GPI	chr19	34884153	+
Frame-shift	ENST00000262233	ENST00000415930	EML1	chr14	100259880	+	GPI	chr19	34884153	+
Frame-shift	ENST00000262233	ENST00000356487	EML1	chr14	100259880	+	GPI	chr19	34884153	+
Frame-shift	ENST00000262233	ENST00000586425	EML1	chr14	100259880	+	GPI	chr19	34884153	+
Frame-shift	ENST00000334192	ENST00000415930	EML1	chr14	100259880	+	GPI	chr19	34884153	+
Frame-shift	ENST00000334192	ENST00000356487	EML1	chr14	100259880	+	GPI	chr19	34884153	+
Frame-shift	ENST00000334192	ENST00000586425	EML1	chr14	100259880	+	GPI	chr19	34884153	+
intron-3CDS	ENST00000556758	ENST00000415930	EML1	chr14	100259880	+	GPI	chr19	34884153	+
intron-3CDS	ENST00000556758	ENST00000356487	EML1	chr14	100259880	+	GPI	chr19	34884153	+
intron-3CDS	ENST00000556758	ENST00000586425	EML1	chr14	100259880	+	GPI	chr19	34884153	+
intron-3CDS	ENST00000327921	ENST00000415930	EML1	chr14	100259880	+	GPI	chr19	34884633	+
intron-3CDS	ENST00000327921	ENST00000356487	EML1	chr14	100259880	+	GPI	chr19	34884633	+
intron-3CDS	ENST00000327921	ENST00000586425	EML1	chr14	100259880	+	GPI	chr19	34884633	+
In-frame	ENST00000262233	ENST00000415930	EML1	chr14	100259880	+	GPI	chr19	34884633	+
In-frame	ENST00000262233	ENST00000356487	EML1	chr14	100259880	+	GPI	chr19	34884633	+
In-frame	ENST00000262233	ENST00000586425	EML1	chr14	100259880	+	GPI	chr19	34884633	+
In-frame	ENST00000334192	ENST00000415930	EML1	chr14	100259880	+	GPI	chr19	34884633	+
In-frame	ENST00000334192	ENST00000356487	EML1	chr14	100259880	+	GPI	chr19	34884633	+
In-frame	ENST00000334192	ENST00000586425	EML1	chr14	100259880	+	GPI	chr19	34884633	+
intron-3CDS	ENST00000556758	ENST00000415930	EML1	chr14	100259880	+	GPI	chr19	34884633	+
intron-3CDS	ENST00000556758	ENST00000356487	EML1	chr14	100259880	+	GPI	chr19	34884633	+
intron-3CDS	ENST00000556758	ENST00000586425	EML1	chr14	100259880	+	GPI	chr19	34884633	+

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FusionProtFeatures for EML1_GPI

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EML1 O00423	GPI P06744

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Fusion gene ID: 11543

FusionGeneSummary for EML1_GPI

FusionProtFeatures for EML1_GPI