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Fusion gene ID: 11518 |
FusionGeneSummary for EMC10_TCTA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EMC10_TCTA | Fusion gene ID: 11518 | Hgene | Tgene | Gene symbol | EMC10 | TCTA | Gene ID | 284361 | 6988 |
| Gene name | ER membrane protein complex subunit 10 | T cell leukemia translocation altered | |
| Synonyms | C19orf63|HSM1|HSS1 | - | |
| Cytomap | 19q13.33 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ER membrane protein complex subunit 10UPF0510 protein INM02hematopoietic signal peptide-containing membrane domain-containing 1hematopoietic signal peptide-containing secreted 1 | T-cell leukemia translocation-altered gene proteinT-cell leukemia translocation-associated gene protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q5UCC4 | P57738 | |
| Ensembl transtripts involved in fusion gene | ENST00000334976, ENST00000376918, ENST00000598585, | ENST00000273590, ENST00000493381, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 3 X 4 X 2=24 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/24*10)=1.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: EMC10 [Title/Abstract] AND TCTA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TCTA | GO:0045671 | negative regulation of osteoclast differentiation | 19560569 |
| Tgene | TCTA | GO:0072675 | osteoclast fusion | 19560569 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG661036 | EMC10 | chr19 | 50982270 | - | TCTA | chr3 | 49453383 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000334976 | ENST00000273590 | EMC10 | chr19 | 50982270 | - | TCTA | chr3 | 49453383 | - |
| 5CDS-intron | ENST00000334976 | ENST00000493381 | EMC10 | chr19 | 50982270 | - | TCTA | chr3 | 49453383 | - |
| 5CDS-3UTR | ENST00000376918 | ENST00000273590 | EMC10 | chr19 | 50982270 | - | TCTA | chr3 | 49453383 | - |
| 5CDS-intron | ENST00000376918 | ENST00000493381 | EMC10 | chr19 | 50982270 | - | TCTA | chr3 | 49453383 | - |
| 5CDS-3UTR | ENST00000598585 | ENST00000273590 | EMC10 | chr19 | 50982270 | - | TCTA | chr3 | 49453383 | - |
| 5CDS-intron | ENST00000598585 | ENST00000493381 | EMC10 | chr19 | 50982270 | - | TCTA | chr3 | 49453383 | - |
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FusionProtFeatures for EMC10_TCTA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EMC10 | TCTA |