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Fusion gene ID: 11448 |
FusionGeneSummary for ELMO1_ADAM12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ELMO1_ADAM12 | Fusion gene ID: 11448 | Hgene | Tgene | Gene symbol | ELMO1 | ADAM12 | Gene ID | 9844 | 8038 |
| Gene name | engulfment and cell motility 1 | ADAM metallopeptidase domain 12 | |
| Synonyms | CED-12|CED12|ELMO-1 | ADAM12-OT1|CAR10|MCMP|MCMPMltna|MLTN|MLTNA | |
| Cytomap | 7p14.2-p14.1 | 10q26.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | engulfment and cell motility protein 1ced-12 homolog 1 | disintegrin and metalloproteinase domain-containing protein 12meltrin-alphametalloprotease-disintegrin 12 transmembrane | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q92556 | O43184 | |
| Ensembl transtripts involved in fusion gene | ENST00000341056, ENST00000396045, ENST00000310758, ENST00000396040, ENST00000442504, ENST00000448602, ENST00000479447, | ENST00000368679, ENST00000368676, ENST00000467145, | |
| Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 13 X 14 X 4=728 |
| # samples | 7 | 17 | |
| ** MAII score | log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(17/728*10)=-2.09840370406099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ELMO1 [Title/Abstract] AND ADAM12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI051281 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000341056 | ENST00000368679 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-3CDS | ENST00000341056 | ENST00000368676 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-intron | ENST00000341056 | ENST00000467145 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-3CDS | ENST00000396045 | ENST00000368679 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-3CDS | ENST00000396045 | ENST00000368676 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-intron | ENST00000396045 | ENST00000467145 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-3CDS | ENST00000310758 | ENST00000368679 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-3CDS | ENST00000310758 | ENST00000368676 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-intron | ENST00000310758 | ENST00000467145 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-3CDS | ENST00000396040 | ENST00000368679 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-3CDS | ENST00000396040 | ENST00000368676 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-intron | ENST00000396040 | ENST00000467145 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-3CDS | ENST00000442504 | ENST00000368679 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-3CDS | ENST00000442504 | ENST00000368676 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-intron | ENST00000442504 | ENST00000467145 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-3CDS | ENST00000448602 | ENST00000368679 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-3CDS | ENST00000448602 | ENST00000368676 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-intron | ENST00000448602 | ENST00000467145 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-3CDS | ENST00000479447 | ENST00000368679 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-3CDS | ENST00000479447 | ENST00000368676 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
| intron-intron | ENST00000479447 | ENST00000467145 | ELMO1 | chr7 | 37214909 | + | ADAM12 | chr10 | 127734650 | - |
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FusionProtFeatures for ELMO1_ADAM12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ELMO1 | ADAM12 |