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Fusion gene ID: 11426 |
FusionGeneSummary for ELL3_DYNLT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ELL3_DYNLT1 | Fusion gene ID: 11426 | Hgene | Tgene | Gene symbol | ELL3 | DYNLT1 | Gene ID | 80237 | 6993 |
| Gene name | elongation factor for RNA polymerase II 3 | dynein light chain Tctex-type 1 | |
| Synonyms | - | CW-1|TCTEL1|tctex-1 | |
| Cytomap | 15q15.3 | 6q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA polymerase II elongation factor ELL3elongation factor RNA polymerase II-like 3 | dynein light chain Tctex-type 1T-complex testis-specific protein 1 homologt-complex-associated-testis-expressed 1-like 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9HB65 | P63172 | |
| Ensembl transtripts involved in fusion gene | ENST00000319359, ENST00000497465, | ENST00000367088, ENST00000367089, ENST00000367085, | |
| Fusion gene scores | * DoF score | 10 X 11 X 1=110 | 1 X 1 X 1=1 |
| # samples | 11 | 1 | |
| ** MAII score | log2(11/110*10)=0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ELL3 [Title/Abstract] AND DYNLT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ELL3 | GO:0006354 | DNA-templated transcription, elongation | 10882741 |
| Hgene | ELL3 | GO:0006368 | transcription elongation from RNA polymerase II promoter | 10882741 |
| Hgene | ELL3 | GO:0032786 | positive regulation of DNA-templated transcription, elongation | 10882741 |
| Hgene | ELL3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10882741 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU934532 | ELL3 | chr15 | 44085299 | + | DYNLT1 | chr6 | 159065771 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000319359 | ENST00000367088 | ELL3 | chr15 | 44085299 | + | DYNLT1 | chr6 | 159065771 | - |
| intron-intron | ENST00000319359 | ENST00000367089 | ELL3 | chr15 | 44085299 | + | DYNLT1 | chr6 | 159065771 | - |
| intron-intron | ENST00000319359 | ENST00000367085 | ELL3 | chr15 | 44085299 | + | DYNLT1 | chr6 | 159065771 | - |
| intron-intron | ENST00000497465 | ENST00000367088 | ELL3 | chr15 | 44085299 | + | DYNLT1 | chr6 | 159065771 | - |
| intron-intron | ENST00000497465 | ENST00000367089 | ELL3 | chr15 | 44085299 | + | DYNLT1 | chr6 | 159065771 | - |
| intron-intron | ENST00000497465 | ENST00000367085 | ELL3 | chr15 | 44085299 | + | DYNLT1 | chr6 | 159065771 | - |
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FusionProtFeatures for ELL3_DYNLT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ELL3 | DYNLT1 |