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Fusion gene ID: 1139 |
FusionGeneSummary for AGPAT3_PDXK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AGPAT3_PDXK | Fusion gene ID: 1139 | Hgene | Tgene | Gene symbol | AGPAT3 | PDXK | Gene ID | 56894 | 8566 |
| Gene name | 1-acylglycerol-3-phosphate O-acyltransferase 3 | pyridoxal kinase | |
| Synonyms | LPAAT-GAMMA1|LPAAT3 | C21orf124|C21orf97|HEL-S-1a|PKH|PNK|PRED79 | |
| Cytomap | 21q22.3 | 21q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma1-AGP acyltransferase 31-AGPAT 3lysophosphatidic acid acyltransferase gammalysophosphatidic acid acyltransferase-gamma1 | pyridoxal kinaseepididymis secretory sperm binding protein Li 1apyridoxal (pyridoxine, vitamin B6) kinasepyridoxamine kinasepyridoxine kinasevitamin B6 kinase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NRZ7 | O00764 | |
| Ensembl transtripts involved in fusion gene | ENST00000291572, ENST00000398061, ENST00000327505, ENST00000398063, ENST00000398058, ENST00000546158, ENST00000479117, | ENST00000398081, ENST00000468090, ENST00000291565, ENST00000327574, ENST00000476313, ENST00000467908, | |
| Fusion gene scores | * DoF score | 13 X 4 X 9=468 | 3 X 3 X 4=36 |
| # samples | 15 | 4 | |
| ** MAII score | log2(15/468*10)=-1.64154602908752 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: AGPAT3 [Title/Abstract] AND PDXK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PDXK | GO:0008283 | cell proliferation | 10930737 |
| Tgene | PDXK | GO:0042823 | pyridoxal phosphate biosynthetic process | 9099727|10987144|17766369 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A07O-01A | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| TCGA | RV | STAD | TCGA-CD-8535-01A | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000291572 | ENST00000398081 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| 5UTR-3CDS | ENST00000291572 | ENST00000468090 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| 5UTR-3CDS | ENST00000291572 | ENST00000291565 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| 5UTR-3CDS | ENST00000291572 | ENST00000327574 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| 5UTR-3UTR | ENST00000291572 | ENST00000476313 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| 5UTR-intron | ENST00000291572 | ENST00000467908 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| 5UTR-3CDS | ENST00000398061 | ENST00000398081 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| 5UTR-3CDS | ENST00000398061 | ENST00000468090 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| 5UTR-3CDS | ENST00000398061 | ENST00000291565 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| 5UTR-3CDS | ENST00000398061 | ENST00000327574 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| 5UTR-3UTR | ENST00000398061 | ENST00000476313 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| 5UTR-intron | ENST00000398061 | ENST00000467908 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| 5UTR-3CDS | ENST00000327505 | ENST00000398081 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| 5UTR-3CDS | ENST00000327505 | ENST00000468090 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| 5UTR-3CDS | ENST00000327505 | ENST00000291565 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| 5UTR-3CDS | ENST00000327505 | ENST00000327574 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| 5UTR-3UTR | ENST00000327505 | ENST00000476313 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| 5UTR-intron | ENST00000327505 | ENST00000467908 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3CDS | ENST00000398063 | ENST00000398081 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3CDS | ENST00000398063 | ENST00000468090 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3CDS | ENST00000398063 | ENST00000291565 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3CDS | ENST00000398063 | ENST00000327574 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3UTR | ENST00000398063 | ENST00000476313 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-intron | ENST00000398063 | ENST00000467908 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3CDS | ENST00000398058 | ENST00000398081 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3CDS | ENST00000398058 | ENST00000468090 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3CDS | ENST00000398058 | ENST00000291565 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3CDS | ENST00000398058 | ENST00000327574 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3UTR | ENST00000398058 | ENST00000476313 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-intron | ENST00000398058 | ENST00000467908 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3CDS | ENST00000546158 | ENST00000398081 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3CDS | ENST00000546158 | ENST00000468090 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3CDS | ENST00000546158 | ENST00000291565 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3CDS | ENST00000546158 | ENST00000327574 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3UTR | ENST00000546158 | ENST00000476313 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-intron | ENST00000546158 | ENST00000467908 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3CDS | ENST00000479117 | ENST00000398081 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3CDS | ENST00000479117 | ENST00000468090 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3CDS | ENST00000479117 | ENST00000291565 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3CDS | ENST00000479117 | ENST00000327574 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-3UTR | ENST00000479117 | ENST00000476313 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
| intron-intron | ENST00000479117 | ENST00000467908 | AGPAT3 | chr21 | 45323900 | + | PDXK | chr21 | 45153950 | + |
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FusionProtFeatures for AGPAT3_PDXK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AGPAT3 | PDXK |