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Fusion gene ID: 11365 |
FusionGeneSummary for EIF5A2_PRKCI |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF5A2_PRKCI | Fusion gene ID: 11365 | Hgene | Tgene | Gene symbol | EIF5A2 | PRKCI | Gene ID | 56648 | 5584 |
| Gene name | eukaryotic translation initiation factor 5A2 | protein kinase C iota | |
| Synonyms | EIF-5A2|eIF5AII | DXS1179E|PKCI|nPKC-iota | |
| Cytomap | 3q26.2 | 3q26.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eukaryotic translation initiation factor 5A-2eIF-5A-2eukaryotic initiation factor 5A | protein kinase C iota typePRKC-lambda/iotaaPKC-lambda/iotaatypical protein kinase C-lambda/iota | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9GZV4 | P41743 | |
| Ensembl transtripts involved in fusion gene | ENST00000295822, ENST00000460117, ENST00000487522, ENST00000474096, | ENST00000295797, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 6 X 6=216 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/216*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EIF5A2 [Title/Abstract] AND PRKCI [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PRKCI | GO:0006468 | protein phosphorylation | 8226978 |
| Tgene | PRKCI | GO:0018105 | peptidyl-serine phosphorylation | 21983565 |
| Tgene | PRKCI | GO:0043524 | negative regulation of neuron apoptotic process | 10467349 |
| Tgene | PRKCI | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 10467349 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | CESC | TCGA-EK-A2R9-01A | EIF5A2 | chr3 | 170626332 | - | PRKCI | chr3 | 170011171 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000295822 | ENST00000295797 | EIF5A2 | chr3 | 170626332 | - | PRKCI | chr3 | 170011171 | + |
| 5UTR-3CDS | ENST00000460117 | ENST00000295797 | EIF5A2 | chr3 | 170626332 | - | PRKCI | chr3 | 170011171 | + |
| 5UTR-3CDS | ENST00000487522 | ENST00000295797 | EIF5A2 | chr3 | 170626332 | - | PRKCI | chr3 | 170011171 | + |
| 5UTR-3CDS | ENST00000474096 | ENST00000295797 | EIF5A2 | chr3 | 170626332 | - | PRKCI | chr3 | 170011171 | + |
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FusionProtFeatures for EIF5A2_PRKCI |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF5A2 | PRKCI |